Sökning: "thioglycoside"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet thioglycoside.

  1. 1. Development of a Novel Promoter System for Thioglycoside Activation; and its application in the synthesis of a GD3 bis-lactam

    Författare :Andréas Meijer; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; GD3; Organic chemistry; bis-lactam; ganglioside; thioglycoside; promoter; iodine monobromide; glycosylation; iodine monochloride; Organisk kemi;

    Sammanfattning : A novel promoter system IX/AgOTf (X=Cl or Br) for thioglycoside activation has been developed (paper I-II). The promoter system has been evaluated in the synthesis of two GD3 bis-lactam fragments (paper III)... LÄS MER

  3. 2. Synthesis of Bacterial Oligosaccharides from N. meningitidis and Mechanistic Details of Stereoselective Glycosylations Using a Novel Bicyclic Donor

    Författare :Johan Olsson; Stefan Oscarson; Jeroen Codée; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; oligosaccharide synthesis; heptose; thioglycoside; glycosylation; Neisseria meningitidis; 2; 3-oxazolidinone; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis includes two parts. The first part, comprising Chapters 3, 4 and 5, describes the synthesis of bacterial oligosaccharides. In Chapters 3 and 4, the synthesis of branched and phosphorylated oligosaccharide structures corresponding to inner core epitopes of the lipopolysaccharide (LPS) of the Gram-negative bacteria N. LÄS MER

  4. 3. Some New Methods in Sialic Acid Chemistry

    Författare :Teddy Ercegovic; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; thioglycoside promoter; ganglioside; Tumor-associated antigen; lactam; lactone; sialic acid; N-acetylneuraminic acid; Neu5Ac; sialyl donor; auxiliary group; 3- S -phenylthio; bis-sialic acid lactam; 3- S -phenylseleno; silver trifluoromethanesulfonate; iodine monochloride; Organic chemistry; Organisk kemi;

    Sammanfattning : Gangliosides (G) are sialic acid-containing cell surface glycosphingolipids capable of forming lactones, i.e. inner esters. Some gangliosides are tumor-associated antigens, and they may serve as immunogens in their lactone form, where the latter is comparatively more abundant on the surface of malignant cells. LÄS MER

  5. 4. Development of strategies for construction of thioglycoside building blocks corresponding to repeating triads of Cryptococcus neoformans GXM capsular polysaccharide

    Författare :Lina Rydner; Stefan Oscarson; Olof Ramström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Crytococcus neoformans; Capsular polysaccharide; Thioglycosides; Convergent synthesis; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis focuses on the development of methods for synthesis of thioglycoside building blocks corresponding to the repeating units of the capsular polysaccharide (CPS) of Cryptococcus neoformans, an opportunistic fungal pathogen. The building blocks are suitable for construction of large synthetic oligosaccharides related to the native CPS-structures which are to be used in biological studies in order to identify protective epitopes with the aim to develop a glycoconjugate vaccine against C. LÄS MER

  7. 5. Dynamic Sulfur Chemistry : Screening, Evaluation and Catalysis

    Författare :Rémi Caraballo; Olof Ramström; Nicolas Giuseppone; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Dynamic combinatorial chemistry; dynamic sulfur chemistry; thioglycoside; mutarotation; disulfide metathesis; hemithioacetal formation; 1H STD-NMR; inhibition; phosphine; Concanavalin A; beta-galactosidase; dynamic drug discovery.; Chemistry; Kemi; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : This thesis deals with the design, formation and evaluation of dynamic systems constructed by means of sulfur-containing reversible reactions, in organic and aqueous media and under mild conditions. In a first part, the synthesis of thioglycoside derivatives, constituting the biologically relevant starting components of the dynamic systems, is described. LÄS MER