Sökning: "RBE"

Visar resultat 16 - 20 av 23 avhandlingar innehållade ordet RBE.

  1. 16. DNA fragmentation in cultured cells exposed to high linear energy transfer radiation

    Författare :Erik Höglund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Sammanfattning : The DNA double-strand break (DSB) is a critical lesion which, if not completely restored, can have serious biological consequences. The relative biological effectiveness (RBE) of many severe end-points are closely related to radiation quality, with increased effectiveness at elevated ionization density. LÄS MER

  3. 17. Radiobiological effects of alpha-particles from Astatine-211: From DNA damage to cell death

    Författare :Kristina Claesson; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : ABSTRACT In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an -particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. LÄS MER

  4. 18. Astatine-211 radioimmunotherapy of ovarian cancer. Therapeutic efficacy, myelotoxicity, andradiation dosimetry in an animal model

    Författare :Jörgen Elgqvist; Göteborgs universitet; []
    Nyckelord :astatine; alpha-particles; monoclonal antibodies; radioimmunotherapy; ; ovarian cancer; myelotoxicity; therapeutic efficacy; radiation dosimetry; fractionation;

    Sammanfattning : Alpha-particle emitting radionuclides have recently obtained an increased attention whenconsidering new strategies for treating disseminated cancer. Astatine (211At), that emits alphaparticleswith a mean path length of 62 μm, a mean linear energy transfer (LET) of 111keV/Mum, and a half-life of 7. LÄS MER

  5. 19. Secondary absorbed dose distributions and radiation quality in light ion therapy

    Författare :Martha Hultqvist; Irena Gudowska; Tatsuhiko Sato; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; secondary doses; light ion therapy; radiation quality; Monte Carlo simulation; Medical Radiation Physics; medicinsk strålningsfysik;

    Sammanfattning : Radiotherapy with light ions offers the possibility of achieving a dose distribution which is highly conformed to the target volume while sparing normal tissues. For ions heavier than protons, an additional advantage is the increased Relative Biological Effectiveness (RBE) as compared to conventional photon and electron beams. LÄS MER

  7. 20. Involvement of Homologous Recombination in Response to Different Qualities of DNA Damage

    Författare :Gunilla Olsson; Mats Harms-Ringdahl; John Thacker; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

    Sammanfattning : The present studies aimed at elucidate the role of homologous recombination (HR) for the repair of different qualities of DNA damages and/or changes in chromatin structure induced by a variety of radiation qualities.Radiation qualities used to expose cells in culture ranged from non-ionizing radiation with extremely low frequency (ELF), of energies too low to disrupt chemical or molecular bonds, to radiation qualities with energies able to induce ionizations and break chemical bonds. LÄS MER