Sökning: "therapeutic efficacy"

Visar resultat 1 - 5 av 275 avhandlingar innehållade orden therapeutic efficacy.

  1. 1. Astatine-211 radioimmunotherapy of ovarian cancer. Therapeutic efficacy, myelotoxicity, andradiation dosimetry in an animal model

    Författare :Jörgen Elgqvist; Göteborgs universitet; []
    Nyckelord :astatine; alpha-particles; monoclonal antibodies; radioimmunotherapy; ; ovarian cancer; myelotoxicity; therapeutic efficacy; radiation dosimetry; fractionation;

    Sammanfattning : Alpha-particle emitting radionuclides have recently obtained an increased attention whenconsidering new strategies for treating disseminated cancer. Astatine (211At), that emits alphaparticleswith a mean path length of 62 μm, a mean linear energy transfer (LET) of 111keV/Mum, and a half-life of 7. LÄS MER

  3. 2. Antimicrobial peptides in the treatment of infectious and inflammatory conditions : Preclinical studies of mechanism of action, efficacy, and safety

    Författare :Camilla Björn; RISE; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance; Antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance;

    Sammanfattning : The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious diseases. AMPs are present in all living species and constitute an important part of the innate immune system in multicellular organisms, including humans. LÄS MER

  4. 3. Computed tomography in endodontic decision making

    Författare :Fernando José Mota de Almeida; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endodontics; decision making; computed tomography; CBCT; cone beam; interviews; qualitative content analysis; diagnostic thinking efficacy; therapeutic efficacy;

    Sammanfattning : Computed tomography has been used in dentistry as a complement to two-dimensional (2D) imaging since the 1980s. The advent of cone beam computed tomography (CBCT), a more modern computed tomog-raphy technique, meant a revolution in dento-maxillofacial imaging due to sharper images, with less radiation and at a lower cost than with mul-ti-slice computed tomography (MSCT), i. LÄS MER

  5. 4. Metabolic and pharmacokinetic study to enhance busulphan therapeutic efficacy

    Författare :Fadwa Benkessou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Busulphan (Bu) is an alkylating agent used in high-doses as part of the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). HSCT is a curative treatment for hematological malignancies and other disorders. Bu can be administered by oral or intravenous route. LÄS MER

  7. 5. Deciphering Binding Patterns of Therapeutic Antibodies with Immune Cells : From Method Development to Application

    Författare :Sina Bondza; Jos Buijs; Marika Nestor; Mark Cragg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity; binding kinetics; CD20; cell-based assay; immunology; receptor-ligand interaction; therapeutic antibody; Immunologi; Immunology; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Reversible binding, for example between signaling molecules and receptors on the cell surface, is one of the main means to communicate information in cellular systems. Knowledge about how molecules interact is crucial for both understanding biological function and for therapeutic intervention. LÄS MER