Sökning: "RBE"

Visar resultat 11 - 15 av 23 avhandlingar innehållade ordet RBE.

  1. 11. Radiation-induced apoptosis in human lymphocytes : studies on expression, function and effects of different radiation qualities

    Författare :Annelie Meijer; Fabrizio Palitti; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Apoptosis; clonogenic survival; growth factors; chromosomal aberrations CA ; low dose-rate LDR ; linear energy transfer LET ; relative biological effectiveness RBE ; radio sensitivity; ataxia telangiectasia A-T ; Physical Biology; fysikalisk biologi;

    Sammanfattning : We are constantly exposed to radiation. Radiation causes damage to our cells. By the removal of damaged and unwanted cells, apoptosis is considered to be one of the most indispensable defence processes for a multi-cellular organism. LÄS MER

  3. 12. From cell survival to dose response : modeling biological effects in radiation therapy

    Författare :Minna Wedenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Radiobiological models;

    Sammanfattning : The main goal in curative radiation therapy is to eradicate the tumor while minimizing radiation-induced damage to normal tissue. Ions, including protons and carbon ions, are increasingly being used for cancer treatment. LÄS MER

  4. 13. Relative biological effectiveness in proton therapy: accounting for variability and uncertainties

    Författare :Jakob Ödén; Iuliana Toma-Dasu; Kjell Eriksson; Radhe Mohan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proton therapy; relative biological effectiveness; linear energy transfer; proton track-end optimisation; radiation-induced toxicity; Medical Radiation Physics; medicinsk strålningsfysik;

    Sammanfattning : Radiation therapy is widely used for treatments of malignant diseases. The search for the optimal radiation treatment approach for a specific case is a complex task, ultimately seeking to maximise the tumour control probability (TCP) while minimising the normal tissue complication probability (NTCP). LÄS MER

  5. 14. The microdosimetric variance-covariance method used for beam quality characterization in radiation protection and radiation therapy

    Författare :Jan Erik Lillhök; Lennart Lindborg; Bernd Grosswendt; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ionizing radiation; radiation quality; radiation protection; radiation therapy; microdosimetry; nanodosimetry; variance-covariance method; Radiological physics; Radiofysik; medicinsk strålningsfysik; Medical Radiation Physics;

    Sammanfattning : Radiation quality is described by the RBE (relative biological effectiveness) that varies with the ionizing ability of the radiation. Microdosimetric quantities describe distributions of energy imparted to small volumes and can be related to RBE. LÄS MER

  7. 15. Monte Carlo particle transport codes for ion beam therapy treatment planning : Validation, development and applications

    Författare :Till Tobias Böhlen; Irena Gudowska; Oliver Jäkel; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Monte Carlo; ion beam therapy; treatment planning; cancer therapy; microdosimetry; Medical Radiation Physics; medicinsk strålningsfysik;

    Sammanfattning : External radiotherapy with proton and ion beams needs accurate tools for the dosimetric characterization of treatment fields. Monte Carlo (MC) particle transport codes, such as FLUKA and GEANT4, can be a valuable method to increase accuracy of dose calculations and to support various aspects of ion beam therapy (IBT), such as treatment planning and monitoring. LÄS MER