Sökning: "collagen induced arthritis"

Visar resultat 1 - 5 av 103 avhandlingar innehållade orden collagen induced arthritis.

1. 1. Collagen induced arthritis : pathogenetic mechanisms and relevance for rheumatoid arthritis

   Författare :Rikard Holmdahl; Uppsala universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : .... LÄS MER

3. 2. The MHC-glycopeptide-T cell interaction in collagen induced arthritis : a study using glycopeptides, isosteres and statistical molecular design in a mouse model for rheumatoid arthritis

   Författare :Lotta Holm; Jan Kihlberg; Morten Grötli; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Rheumatoid arthritis; collagen; T-cell; class II MHC; solid phase peptide synthesis; glycopeptide; peptide isostere; PCA; statistical molecular design; PLS; QSAR; sequence binding motif; Organic chemistry; Organisk kemi;

   Sammanfattning : Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1% of the population in the western world. It is characterised by a tissue specific attack of cartilage in peripheral joints. Collagen induced arthritis (CIA) is one of the most commonly used animal models for (RA), with similar symptoms and histopathology. LÄS MER

4. 3. Immunomodulation of collagen-induced arthritis

   Författare :Lars Mattsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :autoimmunity; arthritis; collagen type II; immunomodulation; vitamin D; parasite;

   Sammanfattning : Collagen-induced arthritis (CIA) is an experimental autoimmune disease sharing many features with human rheumatoid arthritis (RA). CIA development is dependent on T-cells but anti-collagen type II (anti-CII) antibody production by B-cells is also important. LÄS MER

5. 4. Extracellular Matrix Remodelling-Proteoglycan and collagen turnover in arthritis

   Författare :Anette Bjärdahlen; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Arthritis; collagen; cartilage; myofibroblasts; pannus; proteoglycan; Skeleton; muscle system; rheumatology locomotion; reumatologi; Skelett; muskelsystem;

   Sammanfattning : Rheumatoid arthritis is a chronic, inflammatory and systemic disease characterised by joint destruction and pannus formation. To enlarge the understanding how pannus and granulation tissue are formed two animal models were used; one using cartilage wrapped in cotton and implanted into a rat air pouch (AP) and one where mBSA induced arthritis (AIA) was performed. LÄS MER

7. 5. Tolerance Mechanisms in Collagen-Induced Arthritis an Animal Model of Rheumatoid Arthritis

   Författare :Alexandra Treschow; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeleton; Tolerance; Regulation; IFN-beta; Macrophages; Immunology; serology; transplantation; Immunologi; serologi; Arthritis; Collage; rheumatology locomotion; muscle system; Skelett; muskelsystem; reumatologi;

   Sammanfattning : Collagen-induced arthritis (CIA) is one of the most commonly used animal models for Rheumatoid arthritis (RA). CIA is induced in susceptible mouse strains after immunization with heterologous type II collagen (CII). In mice of the H-2q haplotype rat CII (rCII) is used whereas in mice of the H-2r haplotype bovine CII is utilized. LÄS MER