Sökning: "Polyamine"

Visar resultat 11 - 15 av 43 avhandlingar innehållade ordet Polyamine.

  1. 11. Structural Studies of Polyamine Biosynthesis Enzymes: Potential Targets for Drugs against Tropical Parasites

    Författare :Veronica Tamu Dufe; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; inhibitors; protein crystallography; Molecular biophysics; Molekylär biofysik; tropical parasites; polyamine biosynthesis enzymes;

    Sammanfattning : Two enzymes involved in the biosynthesis of polyamines, ornithine decarboxylase (ODC, from human and Leishmania donovani) and spermidine synthase (SPDS, from Plasmodium falciparum and Caenorhabditis elegans) were studied using biochemical methods, homology modelling and X-ray crystallography. ODC catalyses the first and committed step in polyamine biosynthesis, the decarboxylation of ornithine to putrescine. LÄS MER

  3. 12. Effects of polyamine pool manipulation on genes expressed during the cell cycle

    Författare :Pia Berntsson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Animal physiology; cyclin A; ODC; MCF-7; mitotic shake off; DENSPM; CHO; cDNA microarray; cell cycle; spermine; Djurfysiologi; AdoMetDC; 2D gel electrophoresis; polyamines; spermidine; putrescine;

    Sammanfattning : The polyamines - putrescine, spermidine and spermine - are polycations found within cells. They have been shown to be essential for optimal cell proliferation and cell survival. Cells maintain their polyamine levels in a well-regulated system involving biosynthesis, catabolism and uptake/excretion. LÄS MER

  4. 13. Applications of multi-component condensations and development of polyamine synthesis on solid-phase

    Författare :Daniel Jönsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Sammanfattning : Solid-phase synthesis of small non-polymeric molecules has become increasingly important as a tool in the development of pharmacologically active compounds. Of particular interest are the syntheses of compounds with low molecular weight, low polarity and a reduced flexibility of the functional groups, i.e. LÄS MER

  5. 14. Polyamines are involved in the regulation of S phase and DNA synthesis

    Författare :Kersti Alm; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Djurfysiologi; Animal physiology; cell cycle regulation; p53; DNA strand breaks; replicon organization; topoisomerase II;

    Sammanfattning : Our research group has previously shown that treatment with the polyamine biosynthesis inhibitors a-difluoromethylornithine (DFMO) or amidinoindan-1-one 2´-amidinohydrazone (CGP 48664) inhibited S phase progression before any other cell cycle phase was affected. This study was undertaken to further investigate the role of polyamines in the regulation of S phase progression and DNA synthesis. LÄS MER

  7. 15. Polyamines in foods and human milk

    Författare :Mohamed Atiya Ali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :putrescine;

    Sammanfattning : Background: Knowing the levels of polyamines, putrescine, spermidine and spermine in foods and human breast milk, and the contribution of daily food choice to polyamine intake and its effect on the levels in breast milk is of interest, due to the association of these bioactive amines to health and disease. There is a lack of relevant information on the content of polyamines in the Swedish Food Database. LÄS MER