Sökning: "cyclin A"

Visar resultat 1 - 5 av 186 avhandlingar innehållade orden cyclin A.

  1. 1. Cyclin A and cyclin E as prognostic factors in early breast cancer

    Författare :Cecilia Ahlin; Marie-Louise Fjällskog; Carl Blomqvist; Göran Landberg; Uppsala universitet; []
    Nyckelord :Oncology; breast cancer; chemotherapy; cyclin A; cyclin E; aberrant cyclin E; Ki-67; TMA; Onkologi;

    Sammanfattning : Breast cancer is one of the most common malignancies in women. Due to early detection and the use of screening programs approximately 60% of all new cases lack lymph node involvement. Today, a substantial proportion of these women will be offered adjuvant systemic chemotherapy. LÄS MER

  3. 2. Pharmacological and analytical studies of the cyclin dependent kinase inhibitors

    Författare :Hatem H A Sallam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cyclin-dependent kinases (Cdks) play a key role in the regulation of cell cycle progression and RNA transcription. Deregulation of Cdks has been associated with several malignancies, neurodegenerative disorders, viral and protozoal infections, glomerulonephritis and inflammatory diseases. LÄS MER

  4. 3. In vivo studies of cell cycle regulating proteins in rats during liver regeneration and during promotion of liver carcinogenesis

    Författare :Lena Ohlson; Inger Porsvh Hällström; Galina Selivanova; Bertha A. Brodin; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell cycle; cancer; HCC; p53; Rb; p107; G1-progression; G1 S transition;

    Sammanfattning : There are more than one hundred different types of cancer in humans. However, the major platform for all types of cancer is automous and uncontrolled cell division and though most types of cancer are possible to treat and cure by surgery, chemical therapy or irradiation, more efficient and less toxic therapies are urgently needed. LÄS MER

  5. 4. The Prognostic Impact of Proliferation Markers in Breast Cancer with Emphasis on Cyclin B1 and PPH3

    Författare :Anthoula Koliadi; Marie-Louise Fjällskog; Thomas Hatschek; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proliferation; cyclin B1; Phosphorylated Histone 3; cyclin A; breast cancer; node negative; prognostic factor; luminal; Oncology; Onkologi;

    Sammanfattning : The aim of this thesis was to investigate the prognostic role of the proliferation markers cyclin B1 and Phosphorylated Histone 3 (PPH3) in breast cancer (BC).In paper I we used an experimental study design, we compared women dying early from their BC with women free from relapse more than eight years after initial diagnosis. LÄS MER

  7. 5. Immunofluorescence studies on the cell cycle expression of cyclin A and cyclin E

    Författare :Fredrik Erlandsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell cycle regulation; cyclin A; cyclin E; immunofluorescence staining;

    Sammanfattning : Cell cycle progression is tightly regulated in normal eucaryotic cells. Cancer is caused by the transformation of cells, and is always associated with defects in the cell cycle regulatory machinery. LÄS MER