Sökning: "PC12"

Visar resultat 21 - 25 av 46 avhandlingar innehållade ordet PC12.

1. 21. Interactions between neuronal nicotinic acetylcholine receptors, N-methyl-aspartate receptors and beta-amyloid in the brain of genetically modified mice : implications for Alheimer's disease

   Författare :Christina Unger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Abeta; Alzheimer s disease; APP; nAChR; NMDA receptors; synaptophysin; transgenic mice; treatment;

   Sammanfattning : The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's disease (AD) and is based on the theory that hyperproduction and accumulation of amyloid betapeptide (Abeta) in the brain triggers the disruption of neuronal and synaptic function, thereby ultimately leading to neurodegeneration and dementia. Some of the crucial questions are if Abeta has a neuronal function in the brain and how it interacts with the neurotransmitter system in AD. LÄS MER

3. 22. Molecular Characterization of Experimental Traumatic Brain Injury

   Författare :Charlotte Israelsson; Ted Ebendal; Lars Hillered; Anders Lewén; Henrik Hagberg; Uppsala universitet; []
   Nyckelord :Neurosciences; traumatic brain injury; transcripts; GeneChip; chemokine; inflammation; mouse brain; neuroprotection; neuronal injury; neuroregeneration; astrocytosis; Neurovetenskap;

   Sammanfattning : Traumatic brain injury (TBI) is the most common cause of mortality and disability in the younger (.... LÄS MER

4. 23. Molecular characterization of the Tick-borne encephalitis virus : Environments and replication

   Författare :Wessam Melik; Magnus Johansson; Sonja Best; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; molekylärgenetik; Molecular Genetics;

   Sammanfattning : The flavivirus genus is of major concern for world morbidity and mortality and includes viruses causing both encephalitic as well as hemorrhagic diseases. The incidence of Tick-borne encephalitis is increasing in many European countries and several reports have emphasized the expansion of the main vector, Ixodes ricinus. LÄS MER

5. 24. Implantable bioartificial hybrids for targeted therapy in the central nervous system

   Författare :Lars U Wahlberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The rapid increase in the understanding of the CNS at the molecular level has brought us new knowledge and tools to attempt to locally manipulate the CNS microenvironment and thereby introduce reparative and ablative molecular therapeutic approaches in focal areas of the CNS. This targeted therapy will require neurosurgical intervention for the injection and implantation of cells, viral vectors, or drug release systems. LÄS MER

7. 25. Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease

   Författare :Wen-Feng Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Abeta; Alzheimer s disease; astrocytes; brain development; nAChRs; neuritic plaques oxidative stress; transgenic mice; knockout mice;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia with pathological features including the accumulation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). These degenerative processes are also accompanied by impaired cholinergic transmission, oxidative stress, activated glia and inflammation reaction. LÄS MER