Sökning: "Anders Lewén"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Anders Lewén.

  1. 1. Cellular Reactions and Behavioral Changes in Focal and Diffuse Traumatic Brain Injury : A Study in the Rat and Mouse

    Författare :Sara Ekmark Lewén; Lars Hillered; Niklas Marklund; Anders Lewén; Mårten Risling; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; Astrocytes; Inflammatory response; Multivariate concentric square field test; Morris water maze; Exploratory behavior; Risk taking; Functional outcome.; Neurosurgery; Neurokirurgi;

    Sammanfattning : Traumatic brain injury (TBI) is a severe condition and a major cause of death and disability. There is no pharmacological treatment available in clinical practice today and knowledge of brain injury mechanisms is of importance for development of neuroprotective drugs. LÄS MER

  2. 2. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Författare :Anders Lewén; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. LÄS MER

  3. 3. Clinical Bedside Studies of Cerebral Blood Flow in Severe Subarachnoid Hemorrhage Using Xenon CT

    Författare :Henrik Engquist; Per Enblad; Elham Rostami; Anders Lewén; Marianne Juhler; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Subarachnoid hemorrhage; delayed cerebral ischemia; cerebral blood flow; HHH-therapy; triple-H; xenon CT; XeCT; cerebral microdialysis; Neurokirurgi; Neurosurgery;

    Sammanfattning : Aneurysmal subarachnoid hemorrhage (SAH) is frequently complicated by delayed cerebral ischemia (DCI), contributing to poor outcome. Particularly for patients in poor neurological state, prediction of the acute clinical course is difficult, as is the early detection of DCI. LÄS MER

  4. 4. Molecular Characterization of Experimental Traumatic Brain Injury

    Författare :Charlotte Israelsson; Ted Ebendal; Lars Hillered; Anders Lewén; Henrik Hagberg; Uppsala universitet; []
    Nyckelord :Neurosciences; traumatic brain injury; transcripts; GeneChip; chemokine; inflammation; mouse brain; neuroprotection; neuronal injury; neuroregeneration; astrocytosis; Neurovetenskap;

    Sammanfattning : Traumatic brain injury (TBI) is the most common cause of mortality and disability in the younger (.... LÄS MER

  5. 5. Quality systems to avoid secondary brain injury in neurointensive care

    Författare :Lena Nyholm; Per Enblad; Camilla Fröjd; Anders Lewén; Bo-Michael Bellander; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; Subarachnoid hemorrhage; Intracranial pressure; Quality register; Checklist; Nursing interventions; Pressure autoregulation; Intracranial compliance; Hyperthermia; Cerebral energy metabolism; Microdialysis and Brain tissue oxygenation.; Neurokirurgi; Neurosurgery;

    Sammanfattning : Outcome after traumatic brain injury (TBI) depends on the extent of primary cell death and on the development of secondary brain injury. The general aim of this thesis was to find strategies and quality systems to minimize the extent of secondary insults in neurointensive care (NIC). LÄS MER