Sökning: "Nurr1"

Visar resultat 11 - 15 av 27 avhandlingar innehållade ordet Nurr1.

1. 11. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2

   Författare :Elin Andersson; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; cell replacement; Parkinson?s; dopamine; neuronal specification; development; mesencephalon; TH; neuronal differentiation; proneural genes; transcription factors; bHLH; neurospheres; stem cell; progenitor cell;

   Sammanfattning : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. LÄS MER

3. 12. On transplantation of fetal ventral mesencephalon with focus on dopaminergic nerve fiber formation

   Författare :Nina Törnqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :VM; graft; Parkinson s disease; graft reinnervation; striatum; patchy; intraocular transplantation; intracranial transplantation; primary culture;

   Sammanfattning : Poor cell survival and striatal reinnervation are two of the postulated limiting factors of fetal ventral mesencephalic (VM) grafting in Parkinson's disease. It has, however, been reported that an increased survival of VM dopaminergic neurons does not correlate with an enhanced target innervation. LÄS MER

4. 13. On Parkinson's disease and schizophrenia : case control studies, cellular localization and modelling of candidate genes

   Författare :Andrea Carmine; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Genetic; association; dopamine; Parkinson s disease; schizophrenia; retinoid; aldehyde; toxicity;

   Sammanfattning : The causes of many major neurodegenerative, neurodevelopmental and psychiatric diseases are unknown. This thesis has aimed at applying knowledge about the dopamine (DA) neuron system and other key systems to clinical material (DNA and post mortem brain tissue) collected from patients with Parkinson s disease (PD), schizophrenia (SZ) and controls, in order to decipher genetic risk factors. LÄS MER

5. 14. Wnt signalling in the development of ventral midbrain dopaminergic neurons

   Författare :Gonçalo de Sá e Sousa de Castelo-Branco; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Dopaminergic Neuron; Ventral Midbrain Development; Writs; Dickkopf; beta-catenin; GSK-3beta; Stem Cells; Neural Precursors;

   Sammanfattning : Dopaminergic (DA) neurons in the ventral midbrain (VM) are one of the major cell types lost in Parkinson's disease (PD). Proof-of-principle exists for cell replacement therapies for PD, but wider application is halted by the unavailability of abundant sources of DA neurons. Stem cells might constitute one of these sources. LÄS MER

7. 15. Candidate genes and the dopamine system : possible implications in complex neurological and psychiatric disease

   Författare :Silvia Buervenich; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Genetic; linkage; association; dopamine; Parkinsons disease; schizophrenia; bipolar disease; retinoid; aldehyde; toxicity.;

   Sammanfattning : The mesencephalic dopamine (DA) system is strongly involved in the pathogenesis of Parkinsons disease (PD), where symptoms occur after the loss of the vast majority of DA neurons. An involvement of this system also in schizophrenia (SZ) and bipolar disease (BD) is suggested by the fact that DA receptor antagonists are among the most potent drugs in clinical use for the treatment of these conditions. LÄS MER