Sökning: "intracranial transplantation"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden intracranial transplantation.

  1. 1. Intraocular and intracranial transplantation of neural tissue : Studies on hypothalamic and hippocampal neuros

    Författare :Hanna Bergman; Pertti Panula; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Previous studies has demonstrated the possibility to transplant monoaminergic neurons intracranially and to the anterior chamber of the eye, where these neurons continue to develop into functional, transmitter expressing cells. In the present study, investigations were undertaken to examine the development of transplanted hypothalamic and hippocampal neurons in the rat. LÄS MER

  3. 2. On transplantation of fetal ventral mesencephalon with focus on dopaminergic nerve fiber formation

    Författare :Nina Törnqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :VM; graft; Parkinson s disease; graft reinnervation; striatum; patchy; intraocular transplantation; intracranial transplantation; primary culture;

    Sammanfattning : Poor cell survival and striatal reinnervation are two of the postulated limiting factors of fetal ventral mesencephalic (VM) grafting in Parkinson's disease. It has, however, been reported that an increased survival of VM dopaminergic neurons does not correlate with an enhanced target innervation. LÄS MER

  4. 3. Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease

    Författare :Kioumars Delfani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Parkinson s Disease; apoptosis; substantia nigra; dopamine; MPTP; neurogenesis; intracranial transplantation; ATP; PET; stereology; diethyldithiocarbamate; 7-nitroindazole; mouse; squirrel monkey; non- human primate;

    Sammanfattning : We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP). In a series of experiments we assessed the effects of diethyIdithiocarbamate (DDC) on MPTP toxicity, analyzing striatal and midbrain dopamine levels as well as neuronal loss. LÄS MER

  5. 4. Management of Ischemia and Brain Death-Associated Injuries in Porcine Kidney Grafts

    Författare :Amir Sedigh; Tomas Lorant; Gunnar Tufveson; Olle Korsgren; Styrbjörn Friman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Organs from deceased donors after brain death (BD) remain the major source of organs for transplantation. The catastrophic event of BD and the inevitable consequences of ischemia reperfusion injury (IRI) are linked to impaired graft quality and transplantation outcome. LÄS MER

  7. 5. Downstream effects of master regulators in two brain diseases

    Författare :Sebastian Braun; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rett syndrome; brain tumor development; gene regulation; neural stem cells; cell of origin; BMI1;

    Sammanfattning : In paper one, we investigated how the pharmacological activation and inhibition of the glucocorticoid system affects lifespan and symptoms in a mouse model for RTT. We performed a long-term drug treatment study with the GR activator corticosterone and the GR inhibitor RU486 under which we measured the lifespan and onset of RTT-like symptoms of male Mecp2-null and female Mecp2 heterozygous mice in comparison to untreated mutant and to treated and untreated wild-type animals. LÄS MER