Sökning: "leukotriene D4 responsiveness"

Hittade 2 avhandlingar innehållade orden leukotriene D4 responsiveness.

1. 1. Clinical studies of asthma phenotypes focusing on the role of the leukotrienes

   Författare :Per Gyllfors; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :>asthma; aspirin intolerance; leukotrienes; leukotriene D4 responsiveness; methacholine responsiveness; exhaled nitric oxide;

   Sammanfattning : Inflammation in the airways in connection to asthma is a complex phenomenon and the mechanisms underlying the associated clinical symptoms involve the interaction of many different kinds of cells and mediators, giving rise to different phenotypes. The aim of the present thesis was to investigate the molecular and cellular mechanisms that results in two of these phenotypes, i. LÄS MER

3. 2. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle

   Författare :Eva Wikström Jonsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :cysteinyl leukotrienes; leukotriene receptor; histamine; antigen; smooth muscle; lipoxin; thromboxane; Schultz-Dale reaction;

   Sammanfattning : The cysteinyl leukotrienes (leukotriene C4, D4 and E4) have potent biological actions which significantly contribute to the airway obstruction in asthma. Several of these effects are blocked by drugs known as CysLT1-receptor antagonists, which have been introduced as new treatment for asthma. LÄS MER