Sökning: "graft reinnervation"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden graft reinnervation.

  1. 1. Assessment of Graft Effects and Function in Cell Replacement Therapy for Parkinson's Disease

    Författare :Peter Hagell; Äldres hälsa och personcentrerad vård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; measurement; psychometrics; perceived health; dyskinesias; assessment; striatum; positron emission tomography; dopamine; Parkinson s disease; transplantation;

    Sammanfattning : This explorative study aimed to apply, develop, and evaluate assessment methods at various levels in cell replacement therapy for Parkinson’s disease (PD). Observed motor effects in five grafted patients support that timed motor tasks and clinical ratings of parkinsonism are able to monitor motor function, but their psychometric properties need further attention. LÄS MER

  3. 2. On transplantation of fetal ventral mesencephalon with focus on dopaminergic nerve fiber formation

    Författare :Nina Törnqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :VM; graft; Parkinson s disease; graft reinnervation; striatum; patchy; intraocular transplantation; intracranial transplantation; primary culture;

    Sammanfattning : Poor cell survival and striatal reinnervation are two of the postulated limiting factors of fetal ventral mesencephalic (VM) grafting in Parkinson's disease. It has, however, been reported that an increased survival of VM dopaminergic neurons does not correlate with an enhanced target innervation. LÄS MER

  4. 3. Facial nerve injury and microsurgical repair : Experimental and clinical studies

    Författare :Davor Jergovic; Thomas Carlstedt; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Facial palsy is a relatively common clinical condition with a variety of causes. Irrespective of its etiology, facial palsy always represents a very serious problem for the patient. This underlines the need for more effective treatment procedures. LÄS MER

  5. 4. On the influence of glia on neurite outgrowth from dopamine neurons in the nigrostriatal system

    Författare :Malin Saga Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine; glia; astrocytes; olfactory ensheathing cells; development; ni-grostriatal; mesencephalon; Parkinson s disease; 6-hydroxydopamine;

    Sammanfattning : Interactions between glial cells and neurons are important during fetal development, in the maintenance of the normal functions in tile central nervous system (CNS), arid in response to injuries or diseases. Some of die motor disturbances in Parkinson's disease, a neurodegenerative disorder where one of the hallmarks is degeneration of dopamine (DA) neurons and concomitant depletion of DA in striatum, can be alleviated by intrastriatal grafting of embryonic DA tissue. LÄS MER

  7. 5. On CNS injury and olfactory ensheathing cell engraftment strategies

    Författare :I-Hui Lee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) is limited because of lack of nerve-growth stimulatory factors and presence of an insurmountable molecular environment for injured axons. This thesis aims to study neural regeneration following adult CNS injury, using rodent models of spinal cord injury, dorsal root avulsion, and Parkinson s disease. LÄS MER