Sökning: "GSK-3beta"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet GSK-3beta.

  1. 1. Wnt signalling in the development of ventral midbrain dopaminergic neurons

    Författare :Gonçalo de Sá e Sousa de Castelo-Branco; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopaminergic Neuron; Ventral Midbrain Development; Writs; Dickkopf; beta-catenin; GSK-3beta; Stem Cells; Neural Precursors;

    Sammanfattning : Dopaminergic (DA) neurons in the ventral midbrain (VM) are one of the major cell types lost in Parkinson's disease (PD). Proof-of-principle exists for cell replacement therapies for PD, but wider application is halted by the unavailability of abundant sources of DA neurons. Stem cells might constitute one of these sources. LÄS MER

  3. 2. Role of p70 S6 kinase in the formation of tau pathologies in Alzheimer’s disease

    Författare :Wen-Lin An; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; p70 S6 kinase; tau; protein translation; accumulation; phosphorylation;

    Sammanfattning : One of the important neuropathological features of Alzheimer's disease (AD) is the tau pathology seen as accumulation and hyperphosphorylation of this protein. Evidences showed that tau could be phosphorylated mostly at serine/threonine (S/T) residues by many kinases, including protein kinase B, glycogen synthase kinase (GSK)-3beta, extracellular signal-regulated kinase (ERK1/2), ERK1/2 kinase (MEK1/2), c-Jun Nterminal kinase (JNK), and p38. LÄS MER

  4. 3. Tau and neurofilament proteins in Alzheimer’s disease and related cell models

    Författare :Cecilia Björkdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AD; tau; neurofilament proteins; kinases; zinc; Hsp27; alphaB-crystallin;

    Sammanfattning : Background and aims: Among those afflicted with dementia more than half suffer from Alzheimer’s disease (AD). Pathological hallmarks of the disease include aggregates of Abeta, so called amyloid plaques, and neurofibrillary tangles (NFTs) made up of hyperphosphorylated cytoskeletal proteins. LÄS MER

  5. 4. Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha

    Författare :Jenny Öhman; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vascular; hyperglycemia; osteopontin; NFAT; diabetes; retinopathy; TNF; UTP;

    Sammanfattning : Vascular complications of diabetes account for the majority of morbidity and mortality among diabetic patients. Large clinical trials have identified hyperglycemia as a risk factor in the development of diabetic vascular complications. LÄS MER

  7. 5. New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators

    Författare :Ninib Baryawno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Medulloblastoma is an embryonal tumour that mainly affects children. It is the most common malignant brain tumour in children and accounts for 15% of all childhood brain tumours. It most often presents in the cerebellum and is considered to be a disorder of normal development. LÄS MER