Sökning: "Nurr1"

Visar resultat 6 - 10 av 27 avhandlingar innehållade ordet Nurr1.

  1. 6. Nuclear hormone receptor signaling in the developing CNS : studies on the retinoid receptors RAR and RXR, and the orphan receptors NURR1, NOR1 and NGFI-B

    Författare :Ludmila Solomin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear hormone receptor superfamily comprises more than sixty members, including receptors for steroids, thyroid hormone, vitamin D and retinoids. Many nuclear receptors function as ligand-induced transcription factors that upregulate expression of specific target genes. LÄS MER

  3. 7. On natural and drug-induced reward : genetic, biochemical and behavioral comparisons

    Författare :Martin Werme; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :VTA; nucleus accumbens; wheel running; exercise; drugs of abuse; addiction; compulsive; deltaFosB; Nurr1; Dynorphin;

    Sammanfattning : Work in this thesis compares natural and drug- induced reward at genetic, biochemical and behavioral levels with the objective to obtain information about key mechanisms underlying reward and addiction, and improve the understanding of compulsive elements that characterize addiction. Surveys among committed human runners have described running as addictive. LÄS MER

  4. 8. Transcription factor control in neuronal maintenance and survival

    Författare :Banafsheh Kadkhodaei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Transcription factor (TF) Nurr1 is essential for the development of a group of dopamine neurons that are located in the ventral midbrain (also referred to as mesencephalon). A progressive pathology of these midbrain dopamine (mDA) neurons is evident in Parkinson s disease, the most frequent neurodegenerative movement disorder. LÄS MER

  5. 9. Regulation of monoaminergic functions by GPCRs with a special emphasis on mental and movement disorders

    Författare :Ioannis Mantas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dysfunction of the brain’s monoaminergic system has been implicated in many human neurological and psychiatric disorders, such as Parkinson’s disease (PD), major depressive disorder (MDD) and schizophrenia. The monoamines that are most dysregulated in these diseases, are dopamine and serotonin. LÄS MER

  7. 10. Nuclear receptor and Wnt function in developing dopaminergic neurons

    Författare :Kyle Matthew Sousa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The progressive degeneration of dopaminergic neurons in the substantia nigra is one of the major pathological events associated with Parkinson’s Disease. Dopaminergic (DA) cell replacement therapy has emerged in recent years as a possible approach towards treating Parkinsonism. LÄS MER