Sökning: "Neurokemi"

Visar resultat 16 - 20 av 216 avhandlingar innehållade ordet Neurokemi.

1. 16. Proteolytic processing of the Alzheimer APP protein family during neuronal differentiation

   Författare :Sofia Holback; Kerstin Iverfeldt; Nigel Hooper; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; differentiation; processing; retinoic acid; secretase; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Increased amyloid-β (Aβ) load in the brain, neurite degeneration, neuronal loss, and decreased levels of several neurotrophins are among the characteristics of Alzheimer’s disease (AD). Generation of Aβ occurs when the amyloid precursor protein (APP) is proteolytically processed by β- and γ-secretases in the amyloidogenic pathway. LÄS MER

3. 17. Oxidative stress and alterations in the mammalian iron metabolism : A study on iron, inflammation, oxidative stress and neurodegeneration

   Författare :Jonas Hälldin; Tiit Land; Paolo Arosio; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Iron is essential for all living organisms, from bacteria to man for a broad variety of biological functions, including oxygen transport and DNA synthesis. However, iron can also be toxic, due to its involvement in the formation of highly reactive oxygen species through Fenton chemistry. LÄS MER

4. 18. Processing of the APP family by the α-secretases ADAM10 and TACE

   Författare :Kristin Jacobsen; Kerstin Iverfeldt; Lars Nilsson; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by formation of amyloid plaques in the brain. The major constituent of these plaques is the hydrophobic peptide Aβ. Aβ accumulation is considered to be the main cause of the pathology seen in AD brains. LÄS MER

5. 19. Cell-penetrating peptides in protein mimicry and oligonucleotide delivery : Applications and mechanisms

   Författare :Henrik Johansson; Ülo Langel; Michael Gait; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; cell-penetrating peptide; PNA; splicing; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : The plasma membrane functions as a barrier, restricting entry of hydrophilic pharmaceutical agents. Cell-penetrating peptides (CPPs) are capable of transporting bioactive cargos into the cell and have consequently been extensively investigated for their mechanism of entry and capability to deliver various cargos spanning from peptides to plasmids. LÄS MER

7. 20. Cell-penetrating peptides as delivery vectors for oligonucleotides and proteins : Studies on applications and toxicity

   Författare :Peter Järver; Ülo Langel; Gilles Divita; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Cell-penetrating peptides (CPPs) have for a little bit more than a decade been employed as delivery vectors for a wide range of cargoes, ranging from gold particles to entire plasmids. Although CPP are well studied and utilized in numerous publications, our knowledge about CPP mediated transport is still poor. LÄS MER