Sökning: "Neurokemi"

Visar resultat 6 - 10 av 216 avhandlingar innehållade ordet Neurokemi.

1. 6. Altered cell signaling linked to neurodegeneration : Studies on scrapie-infected neuroblastoma cells and activated microglia

   Författare :Christina Svensson; Tiit Land; Gianluigi Forloni; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prion disease; Inflammation; MAPK; Microglia activation; Neuroblastoma; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

   Sammanfattning : Prion diseases are neurodegenerative disorders that can affect humans and animals. The underlying event is a conformational change of the normal cellular prion protein (PrPC) into an aberrant isoform termed PrP-scrapie (PrPSc). PrPSc is thought to lead to neurodegeneration and activation of glial cells. LÄS MER

3. 7. The Interleukin-1 family of proteins in the brain and adrenal gland : regulation in response to bacterial LPS

   Författare :Susanne Tingsborg; Fred J.H. Tilders; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

   Sammanfattning : Interleukin-1 (IL-1) is mediating diverse physiological conditions as inflammatory response, fever and sickness behaviour but also, via activation of the hypothalamus-pituitary-adrenal (HPA)-axis, the release of the anti-inflammatory adrenocorticoids. The neuroendocrine system as well as the central nervous system (CNS) is involved in the regulation of these conditions in the body. LÄS MER

4. 8. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies

   Författare :Maria Wanderoy; Eliassitet Eriksson; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

   Sammanfattning : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. LÄS MER

5. 9. Processing of the amyloid precursor protein and its paralogues amyloid precursor-like proteins 1 and 2

   Författare :Linda Adlerz; Kerstin Iverfeldt; Richard Cowburn; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; Alzheimer s disease; Amyloid β-peptide; Processing; RA; BDNF; IGF-1; curcumin; PI3-K; MAPK; cdk5; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. LÄS MER

7. 10. Development of a new protective group for tryptophan

   Författare :Marie Danielsson; Anders Undén; Amelie Karlström; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : A new protective group for the indole nitrogen of the amino acid tryptophan, the Boc-sarcosinoyl-sarcosinolyl (Boc-Sar-Sar) is described. This protective group shows good stability to the reaction conditions used in solid phase peptide synthesis and is incorporated into the peptide as FmocTrp(BocSarSar)OH. LÄS MER