Sökning: "NS3"

Visar resultat 16 - 20 av 45 avhandlingar innehållade ordet NS3.

  1. 16. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors

    Författare :Anja Johansson; Montse Llinàs-Brunet; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Hepatitis C Virus (HCV) is the leading cause of chronic liver disease worldwide as well as the primary indication for liver transplantation. More than 3% of the world’s population is chronically infected with HCV and there is an urgent need for effective therapy. LÄS MER

  3. 17. Design and Synthesis of Enzyme Inhibitors Against Infectious Diseases : Targeting Hepatitis C Virus NS3 Protease and Mycobacterium tuberculosis Ribonucleotide Reductase

    Författare :Johan Gising; Mats Larhed; Anders Karlén; Victor Snieckus; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Infectious diseases, including hepatitis C and tuberculosis, claim the lives of over 15 million people each year. Hepatitis C is caused by the hepatitis C virus (HCV) which infects the liver and can ultimately result in liver transplantation. HCV is very adaptive as a result of its high mutation rate. LÄS MER

  4. 18. Peptide-Based Inhibitors of Hepatitis C Virus NS3 Serine Protease: Kinetic Aspects and Inhibitor Design

    Författare :Anton Poliakov; Helena Danielson; Boris Turk; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; serine protease; inhibitor; slow-binding; protein purification; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Hepatitis C is a serious disease that affects about 200 million people worldwide. No anti-HCV vaccine or specific anti-viral drugs are available today. Non-structural protein 3 (NS3) of HCV is a bifunctional serine protease/helicase, and the protease has become a prime target in the search for anti-HCV drugs. LÄS MER

  5. 19. Rational design and synthesis of protease inhibitors : targeting HIV-1, Malaria Plm I and II and Hepatitis C virus NS3 proteases

    Författare :Karin Oscarsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : .... LÄS MER

  7. 20. Discovery and evaluation of direct acting antivirals against hepatitis C virus

    Författare :Eldar Abdurakhmanov; Helena Danielson; David Frick; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Direct acting antivirals; Hepatitis C; NS3-4A protease; NS5B polymerase; structure-based drug discovery; fragment-based drug discovery; surface plasmon resonance; Biokemi; Biochemistry;

    Sammanfattning : Until recently, the standard therapy for hepatitis C treatment has been interferon and ribavirin. Such treatment has only 50% efficacy and is not well tolerated. The emergence of new drugs has increased the treatment efficacy to 90%. LÄS MER