Sökning: "NS3-4A protease"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden NS3-4A protease.

  1. 1. Discovery and evaluation of direct acting antivirals against hepatitis C virus

    Författare :Eldar Abdurakhmanov; Helena Danielson; David Frick; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Direct acting antivirals; Hepatitis C; NS3-4A protease; NS5B polymerase; structure-based drug discovery; fragment-based drug discovery; surface plasmon resonance; Biokemi; Biochemistry;

    Sammanfattning : Until recently, the standard therapy for hepatitis C treatment has been interferon and ribavirin. Such treatment has only 50% efficacy and is not well tolerated. The emergence of new drugs has increased the treatment efficacy to 90%. LÄS MER

  3. 2. Design & Synthesis of Protein Interacting Affinity Ligands and Protease Inhibitors

    Författare :Charlotta Lindquist; Hans Adolfsson; Fredrik Almqvist; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : There is a growing need of both protein drugs and synthetic drugs in the fight against many life-threatening diseases. The first part of this thesis deals with the design and synthesis of high affinity binding ligands for the purification of protein drugs. LÄS MER

  4. 3. Development of a therapeutic vaccine against the hepatitis C virus

    Författare :Gustaf Ahlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; NS3; DNA vaccine; electroporation;

    Sammanfattning : The hepatitis C virus (HCV) infection is a major cause of liver disease and it is estimated that 170 million people worldwide are chronically infected by HCV. There are no protective or curable vaccines available for HCV, however treatment consisting of interferon-α and ribavirin is curative in 45-75% of the chronic infected patients, depending on the viral genotype. LÄS MER

  5. 4. Development of vaccines and experimental models for chronic infections caused by the hepatitis C virus

    Författare :Lars Frelin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; chronic infection; DNA vaccine; NS3; viral vectors; transgenic mice;

    Sammanfattning : The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. It is estimated that HCV affects approximately 170 million people around the world. One feature of HCV infection is the high rate of viral persistence. LÄS MER

  7. 5. The hepatitis C virus and immune escape : relation between sequence variations and the in vitro and in vivo functionality of the non-structural 3/4A complex

    Författare :Jonas Söderholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; NS3; HLA-A2; viral fitness; DNA vaccine;

    Sammanfattning : The hepatitis C virus (HCV) is a blood-borne virus responsible for a major part of liver transplants is the US, and 3% of the population world-wide is infected globally. HCV belongs to the Hepacivirus genus of the Flaviviridae family and is transmitted through infectious blood or blood products. LÄS MER