Sökning: "NS3"

Visar resultat 11 - 15 av 45 avhandlingar innehållade ordet NS3.

1. 11. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Incorporating a P2 Cyclopentane-Derived Scaffold

   Författare :Marcus Bäck; Anja Sandström; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HCV; NS3 protease; Proline mimic; Cyclopentane-derived scaffold; Linear inhibitors; Macrocyclic inhibitors; Organic synthesis; Organisk syntes;

   Sammanfattning : This thesis describes the design, synthesis and structure-activity relationships analysis of potential inhibitors targeting the hepatitis C virus (HCV) NS3 protease. Also discussed is the disease caused by HCV infection and the class of enzymes known as proteases. LÄS MER

3. 12. Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Protease : Focus on C-Terminal Acyl Sulfonamides

   Författare :Robert Rönn; Anders Hallberg; Anja Sandström; Federico Corelli; Uppsala universitet; []
   Nyckelord :Pharmaceutical chemistry; hepatitis C virus; HCV; NS3 protease inhibitor; acyl sulfonamide; bioisostere; palladium; carbonylation; microwave; molybdenum hexacarbonyl; Farmaceutisk kemi;

   Sammanfattning : Hepatitis C is a global health problem that affects approximately 120–180 million people. This viral infection causes serious liver diseases and the therapy available suffers from low efficiency and severe side effects. Consequently, there is a huge unmet medical need for new therapeutic agents to combat the hepatitis C virus (HCV). LÄS MER

4. 13. On the Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : From Tripeptides to Achiral Compounds

   Författare :Pernilla Örtqvist; Anja Sandström; Mats Larhed; Anders Hallberg; Morten Grøtli; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis C virus; NS3 protease inhibitor; structure-activity relationship; resistance; 2 1H -pyrazinone; phenylglycine; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Infection by the hepatitis C virus (HCV) leads to inflammation of the liver, i.e. hepatitis. The acute infection often progresses to a chronic phase during which the liver function is gradually impaired. LÄS MER

5. 14. Computational Studies of Macrocycles and Molecular Modeling of Hepatitis C Virus NS3 Protease Inhibitors

   Författare :Hiba Alogheli; Anders Karlén; Anja Sandström; Peter Brandt; Leif Eriksson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug discovery; HCV NS3 protease; macrocycles; conformational analysis; docking.; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Computational tools are utilized in the drug discovery process to discover, design, and optimize new therapeutics. One important approach is structure-based drug design which relies on knowledge about the 3D structure of the biological target. LÄS MER

7. 15. Design and Synthesis of Acyclic and Macrocyclic Peptidomimetics as Inhibitors of the Hepatitis C Virus NS3 Protease

   Författare :Anna Lampa; Anja Sandström; Youla Tsantrizos; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitor; structure-activity relationship; phenylglycine; ring-closing metathesis; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Hepatitis C is a blood-borne disease affecting 130-170 million people worldwide. The causative agent, hepatitis C virus (HCV), infects the liver and is the major reason for chronic liver disease worldwide. The HCV NS3 protease, a key enzyme in the virus replication cycle, has been confirmed to be an important target for drug development. LÄS MER