Sökning: "Mucositis"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet Mucositis.

1. 1. Pain in pediatric oncology : Explorative and interventional studies focusing on oral mucositis

   Författare :Tove Kamsvåg; Gustaf Ljungman; Louise von Essen; Johan Arvidson; Stefan Nilsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Children; Pain; Oncology; Mucositis; Hematopoietic Stem Cell Transplantation; Pediatrik; Pediatrics;

   Sammanfattning : The aim of this thesis was to examine the prevalence of pain in children treated for cancer with a special focus oral mucositis. In addition, we wanted to examine if oral cryotherapy (OC) could reduce the incidence of severe oral mucositis in children undergoing hematopoietic stem cell transplantation (HSCT), and explore new methods to implement OC. LÄS MER

3. 2. Anthracyclines : Toxicity and chemotherapy-induced mucositis

   Författare :Fredrik Kullenberg; Hans Lennernäs; Erik Sjögren; David Dahlgren; Femke Heindryckx; Henrik Rönnberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anthracycline; doxorubicin; idarubicin; toxicity; intracellular concentration; IC50; chemotherapy-induced mucositis; apoptosis; proliferation; permeability; anti-inflammatory drugs; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Anthracyclines belong to a class of cytostatic compounds that are commonly used to treat various types of cancers, including lymphoma, breast cancer and primary liver cancer. The aim of this thesis was to study how two anthracyclines, doxorubicin and idarubicin, induced cytotoxicity in tumor cells, as well as their off-target effect on the gastrointestinal system. LÄS MER

4. 3. Mucositis Prevention for Patients Receiving High Dose Chemotherapy and Stem Cell Transplantation : Preventive Strategies - There is Always More to do

   Författare :Anncarin Svanberg; Gunnar Birgegård; Kerstin Öhrn; Sharon Elad; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oral mucositis; stem cell transplantion; oral cryotherapy; cooling; cytokine IL-6;

   Sammanfattning : The aim of this thesis was to investigate oral cryotherapy (OC) as prophy-laxis against oral mucositis (OM) in patients given high-dose chemotherapy for stem cell transplantation (SCT). A new mouth rinse device was tested for possible additive effect to OC.For study I-III, 78 patients were randomised to OC or standard oral care (SOC). LÄS MER

5. 4. Preclinical Studies for Cryoprevention of Oral Mucositis

   Författare :Java Walladbegi; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Animal model; Chemotherapy; Cryotherapy; Hematopoietic stem cell transplantation; Ice chips; Intraoral cooling device; Microcirculation; Randomized controlled trial; Tissue-engineered oral mucosa; Tissue oxygen saturation; Tolerability;

   Sammanfattning : Oral mucositis (OM) is a debilitating adverse effect, with a prevalence of up to 80% in patients with cancer who are conditioned with high-dose chemotherapy prior to hematopoietic stem cell transplantation. In its mildest form, OM is characterized by erythema. However, as it worsens, it can give rise to painful ulcerations in the oral mucosa. LÄS MER

7. 5. Oral mucositis and periodontal disease in patients with primary or acquired immunodeficiencies

   Författare :Ying Ye; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The infection and inflammation in the oral cavity are commonly related to the skewed interaction between host immunity and inhabiting microorganisms. Both primary and acquired immunodeficiency conditions are frequently associated with oral symptoms. LÄS MER