Sökning: "anti-inflammatory drugs"

Visar resultat 1 - 5 av 134 avhandlingar innehållade orden anti-inflammatory drugs.

  1. 1. Uridine, 4-thiouridine and isomaltitol in an asthma-like model : Anti-inflammatory and modulating effects

    Författare :Chamilly Evaldsson; Srinivas Uppugunduri; Margareta Linden; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Uridine; asthma; 4-thiouridine; isomaltitol; isomalt; inflammation; eosinophilia; Sephadex; animal model; rat; Pharmaceutical pharmacology; Farmaceutisk farmakologi; MEDICINE; MEDICIN; Lung diseases; Lungsjukdomar;

    Sammanfattning : In chronic inflammatory diseases like asthma or rheumatoid arthritis, erroneous and exaggerated accumulation of leukocytes in a tissue inadvertently causes the body harm. Several efficient anti-inflammatory drugs exist, for example corticosteroids and cyclo-oxygenase inhibitors. LÄS MER

  3. 2. Non-Steroidal Anti-Inflammatory Drugs in Cyclooxygenases 1 and 2 : Binding modes and mechanisms from computational methods and free energy calculations

    Författare :Yasmin Shamsudin Khan; Johan Åqvist; Hugo Gutiérrez de Terán; Xavier Barril; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; molecular dynamics simulations; binding free energy; molecular docking; cyclooxygenase; non-steroidal anti-inflammatory drugs; free energy perturbation; potentials of mean force;

    Sammanfattning : Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of drugs. They target the cyclooxygenases (COX) 1 and 2 to reduce the physiological responses of pain, fever, and inflammation. Due to their role in inducing angiogenesis, COX proteins have also been identified as targets in cancer therapies. LÄS MER

  4. 3. Oxidative stress and proteolysis in the lens. Effects of anti-inflammatory drugs

    Författare :Anne Kling-Petersen; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidation NSAIDs ASA dexamethasone apoptosis GSH GSSG proteasome lens epithelial cells mouse lens cataract;

    Sammanfattning : Oxidative stress has been implied in formation of age-related cataract. The objectives of this thesis were to study redox regulation of proteolysis and oxidative/antioxidative effects of anti-inflammatory substances in human lens epithelial cells (HLEC) and intact mouse lenses. LÄS MER

  5. 4. Fatty acid amide hydrolase - A target for anti-inflammatory therapies?

    Författare :Sandra Holt; Christopher J Fowler; Anders Bucht; Gunnar Tiger; Ruth A Ross; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; FAAH; anandamide; endocannabinoid; pH; inflammation; NSAID; Farmakologi; Pharmacological research; Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : Anti-inflammatory drugs are a widely used class of therapeutic agents, but the use of non-steroidal anti-inflammatory drugs (NSAID) is hampered by their gastrointestinal side-effects. Recent reports that cyclooxygenase-2 inhibitors may cause cardiovascular events underline the importance of identifying new therapeutic strategies for the treatment of inflammation. LÄS MER

  7. 5. Exploring evolutionary and chemical space using chemoinformatic tools and traditional methods in pharmacognosy

    Författare :Astrid Henz Ryen; Anders Backlund; Thierry Kogej; Fernando B. Da Costa; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; angiosperm chemistry; physicochemical properties of plant specialized metabolites; chemical diversity; chemical space; sesquiterpene lactones; scaffold diversity; molecular framework; cluster analysis; ECFP6; Lindera benzoin; sesquiterpenes; anti-inflammatory; Farmakognosi; Pharmacognosy;

    Sammanfattning : The number of new drugs coming to the market is declining while interest in lead discovery from natural resources is seeing a revival. Although methods for isolation and identification of natural products have advanced tremendously, methods for selection of potential leads have fallen behind. LÄS MER