Sökning: "Mass Spectrometry MS"

Visar resultat 11 - 15 av 430 avhandlingar innehållade orden Mass Spectrometry MS.

  1. 11. Organic Phosphorus Compounds in Aquatic Sediments : Towards Molecular Identification with Mass Spectrometry

    Författare :Heidi De Brabandere; Monica Waldebäck; Emil Rydin; Per J. R. Sjöberg; Rolf Danielsson; William T. Cooper; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; electrospray ionisation; mass spectrometry; liquid chromatography; organic phosphorus; aquatic sediment; eutrophication; sample preparation; extraction; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Phosphorus (P) regulates trophic status in most aquatic systems. However, only bioavailable P contributes to primary production. In most lakes and shallow seas, mineralisation of sediment P into its bioavailable form and its release to the water column is important for maintaining primary production. LÄS MER

  3. 12. An Organic Chemistry Odyssey : Imaging Mass Spectrometry in Neurotherapeutics, Asymmetric Methodology Development and Natural Product Synthesis

    Författare :Marvin Villacrez; Kemisk biologi med inriktning mot läkemedelsutveckling; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Masspektrometri; totalsyntes; avbildande massspektrometri; MALDI avbildande massspektrometri; asymmetrisk syntes; farmakokinetik; dynamisk kinetisk resolution; Aasymetrisk överföringshydrogenering; klozapin; Läkemedelsmetabolism; läkemedelsdistribution; aminoalkoholer; Aspidophylline A; mass spectromery; Imaging mass spectrometry; Total synthesis; Dynamic kinetic resolution; asymmetric transfer hydrogenation; Aspidophylline A; Drug distribution; Drug metabolism; Drug Metabolism and Mass Spectrometry Imaging; MALDI mass spectrometry imaging; clozapine; amino alcohols; pharmacokinetics;

    Sammanfattning : The development of imaging technologies and brain models is crucial for advancements in neurotherapeutic drug discovery and development. They assume a critical role in evaluating essential parameters such as drug blood-brain barrier (BBB) permeation, distribution, and metabolism, all of which are vital for the development of safe and effective medications. LÄS MER

  4. 13. Mass spectrometry based analysis of endogenous sterols and hormones

    Författare :Neil de Kock; Jonas Bergquist; Kumari Ubhayasekera; William J. Griffiths; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; supercritical fluid chromatography; UPSFC–MS MS; bioanalysis; steroids; oxysterols; thyroid hormones; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Bioanalytical applications using supercritical fluid chromatography (SFC) as analytical technique are of increasing interest. In essence, bioanalysis involves measurement of bioactive or endogenous compounds in biological matrices. LÄS MER

  5. 14. Structural Determination of Drug Metabolites from Doping Classed Compounds Using Mass Spectrometry

    Författare :Annelie Hansson; Mikael Hedeland; Ulf Bondesson; Peter Hemmersbach; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry; UHPLC-MS MS; doping control; Cunninghamella elegans; selective androgen receptor modulator; SARM; andarine; ostarine; LGD-4033; roxadustat; HIF stabilizer; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : Doping control in equine sports is important for a fair competition, but also to ensure the integrity of the betting system, as well as for animal welfare reasons. To detect the use of illicit compounds, screening for the parent compound is common. However, by using a metabolite as the analytical target instead, the detection time can be prolonged. LÄS MER

  7. 15. Secondary and Higher Order Structural Characterization of Peptides and Proteins by Mass Spectrometry

    Författare :Christopher Adams; Roman Zubarev; Göran Possnert; Carlito Lebrilla; Uppsala universitet; []
    Nyckelord :Engineering physics; Protein Structure; Mass Spectrometry; Electron Capture Dissociation; Tandem Mass Spectrometry; Teknisk fysik;

    Sammanfattning : The work in this thesis has demonstrated the advantages and limitations of using MS based technologies in protein and peptide structural studies. Tandem MS, specifically electron capture dissociation (ECD) have shown the ability to provide structural insights in molecules containing the slightest of all modifications (D-AA substitution). LÄS MER