Sökning: "snRNP"

Hittade 4 avhandlingar innehållade ordet snRNP.

  1. 1. Nuclear Organization of Gene Expression in Adenovirus Infected Cells

    Författare :Anders Aspegren; Lars Wieslander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Adenovirus; mRNA; transport; IGCs; E434kDa; E1B55kDa; NES; snRNP; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Adenovirus infected cells provide a good model system for studying nuclear organization during RNA production and transport. This thesis is focused on the dynamic organization of splicing factors during the late phase of Adenovirus infection in HeLa cells, the nuclear localization of viral RNA, and the pathway used for viral RNA transport to the cytoplasm. LÄS MER

  3. 2. Regulation of adenovirus alternative pre-mRNA splicing : Functional characterization of exonic and intronic splicing enhancer elements

    Författare :Bai-Gong Yue; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; adenovirus; pre-mRNA splicing; splicing enhancer; MLTU; L1; SR protein; ASF SF2; E. coli; phosphorylation; dephosphorylation; Biokemi; Biochemistry; Biokemi; mikrobiologi; Microbiology;

    Sammanfattning : Pre-mRNA splicing and alternative pre-mRNA splicing are key regulatory steps controlling geneexpression in higher eukaryotes. The work in this thesis was focused on a characterization of thesignificance of exonic and intronic splicing enhancer elements for pre-mRNA splicing. LÄS MER

  4. 3. Biochemical and structural studies of pre-mRNA splicing

    Författare :Ingela Wetterberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gene expression; pre-mRNA processing; transcription; in situ; electron tomography;

    Sammanfattning : When eucaryotic genes are expressed, they are transcribed into pre-mRNAs (precursor mRNAs) that need extensive processing before they can be exported from the nucleus as mRNAs and translated into proteins in the cytoplasm. One central processing event is splicing, which means removal of intervening, non-coding sequences, introns and joining of functional sequences, exons. LÄS MER

  5. 4. Mixed connective tissue disease, myositis and systemic lupus erythematosus : immunological and genetic studies in three related rheumatic autoimmune studies

    Författare :Adla Bakri Hassan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MCTD; SLE; PM DM; autoantibodies; cytokines; MHC; polymorphisms.;

    Sammanfattning : Mixed connective tissue disease (MCTD), polymyositis (PM)/ dermatomyositis (DM) and systemic lupus erythematosus (SLE) are chronic, rheumatic, systemic inflammatory disorders. The disorders depend on several factors of both genetic and environmental origin. LÄS MER