Sökning: "oxysterols"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet oxysterols.

  1. 1. Effects of hypoxia on macrophage function in atherosclerosis

    Författare :Ellen Knutsen Rydberg; Göteborgs universitet; []
    Nyckelord :atherosclerosis; hypoxia; macrophage; IL-8; oxidized LDL; oxysterols; 15-lipoxygenase-2;

    Sammanfattning : Atherosclerosis is a complex disease, which affects large and medium sized arteries and is characterized by an arterial wall thickening. A constant supply of oxygen is needed to maintain cell functions in the atherosclerotic plaque. The oxygen distribution to the cells in the arterial wall depends on diffusion. LÄS MER

  3. 2. Mass spectrometry based analysis of endogenous sterols and hormones

    Författare :Neil de Kock; Jonas Bergquist; Kumari Ubhayasekera; William J. Griffiths; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; supercritical fluid chromatography; UPSFC–MS MS; bioanalysis; steroids; oxysterols; thyroid hormones; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Bioanalytical applications using supercritical fluid chromatography (SFC) as analytical technique are of increasing interest. In essence, bioanalysis involves measurement of bioactive or endogenous compounds in biological matrices. LÄS MER

  4. 3. Studies on oxysterols : origins, properties and roles

    Författare :Steve Meaney; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytochrome P-450; oxysterols; cholesterol homeostasis;

    Sammanfattning : Oxysterols are derivatives of cholesterol present at low concentrations in a variety of physiological compartments. The major oxysterols in human circulation are formed from pools of cholesterol that may be distinguished by their miscibility with plasma cholesterol. LÄS MER

  5. 4. Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol

    Författare :Hanna Nylén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about 50% of all drugs. LÄS MER

  7. 5. Side-chain oxidized oxysterols as metabolic regulators in vivo

    Författare :Zeina M F Ali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxysterols are oxygenated derivatives of cholesterol characterized by a very short half- life and their ability to pass lipophilic membranes easily, and they are considered as important intermediates in the excretion pathways of cholesterol and its conversion to bile acids. Evidence has been presented that the production and flux of oxysterols in the brain may also be of some importance for cognitive functions. LÄS MER