Sökning: "roxadustat"

Hittade 2 avhandlingar innehållade ordet roxadustat.

  1. 1. Structural Determination of Drug Metabolites from Doping Classed Compounds Using Mass Spectrometry

    Författare :Annelie Hansson; Mikael Hedeland; Ulf Bondesson; Peter Hemmersbach; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry; UHPLC-MS MS; doping control; Cunninghamella elegans; selective androgen receptor modulator; SARM; andarine; ostarine; LGD-4033; roxadustat; HIF stabilizer; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : Doping control in equine sports is important for a fair competition, but also to ensure the integrity of the betting system, as well as for animal welfare reasons. To detect the use of illicit compounds, screening for the parent compound is common. However, by using a metabolite as the analytical target instead, the detection time can be prolonged. LÄS MER

  3. 2. Mechanistic Based Pharmacokinetic-Pharmacodynamics models for Drug Interactions and Disease Population Predictions

    Författare :Luna Prieto Garcia; Erik Sjögren; Aleksandra Galetin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiologically-Based Pharmacokinetics; Pharmacokinetics; Pharmacodynamics; Disease Modelling; Drug Interactions; Statins; Mechanistic Modelling; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : Therapeutic dose of a medication refers to the quantity of a drug required to produce a pharmacological effect without causing unacceptable adverse events. Dose selection in the clinical setting is not straight forward due to various factors, including specific patient factors such as age, sex, weight, genetic variants and renal/hepatic function, as well as external factors such as food and co-medication, all of which can influence the efficacy and safety of a drug. LÄS MER