Sökning: "MDM2 inhibitors"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden MDM2 inhibitors.

  1. 1. Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors

    Författare :Mariell Pettersson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interactionProtein-protein interaction; MDM2 p53 interaction; MDM2 inhibitors; α- helix mimetics; β-hairpin; 2; 5-diketopiperazine; spiro-2; 5-diketopiperazine; purine; 8- triazolyl purine; solution conformational analysis; NAMFIS; fluorescence;

    Sammanfattning : Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its involvement in DNA repair, induction of cell cycle arrest and cellular apoptosis. LÄS MER

  3. 2. Targeting the GH/IGF-1 axis with novel, small molecule inhibitors

    Författare :Linda Rosengren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The growth hormone (GH) / insulin-like growth factor (IGF) family of ligands, binding proteins and receptors play multiple roles in cell growth, metabolism and development. In addition, numerous studies have demonstrated the pathophysiological importance of the GH/IGF-1 axis. LÄS MER

  4. 3. Targeting insulin-like growth factor-1 receptor in cancer

    Författare :Ada Girnita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF1; IGF-1R; MDM2; p53; PPP; Tamoxifen; tyrosine kinase inhibitors; ubiquitin;

    Sammanfattning : Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. During the selection process towards a malignant phenotype, the transforming cells make use of normal (physiological) extracellular signaling pathways to create growth advantage over normal cells. LÄS MER

  5. 4. Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway

    Författare :Naida Suleymanova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its Mdm2-dependent ubiquitination and degradation followed by MAPK signaling. LÄS MER

  7. 5. Exploring the therapeutic effects of p53 modulation in cancer and immune cell biology

    Författare :Katrine Ingelshed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor suppressor protein p53 is dysregulated in almost all cancer. In around 50% of cancer p53 retains wild type activity but its inactivation by the E3 ligase MDM2 in a heterodimer complex with MDMX may be amplified, leading to loss of p53 activity. LÄS MER