Sökning: "MDM2 p53 interaction"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden MDM2 p53 interaction.
1. Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors
Sammanfattning : Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its involvement in DNA repair, induction of cell cycle arrest and cellular apoptosis. LÄS MER
2. Evolution of Interactions Involving Intrinsically Disordered Proteins
Sammanfattning : This thesis describes the evolution of intrinsically disordered proteins and their interaction partners. The work presented is a combination of phylogenetic analysis, ancestral reconstruction and biophysical characterization in order to examine the evolutionary trajectory of protein-protein interactions involving disorder. LÄS MER
3. Pharmacological targeting of p53 pathway alterations in tumors
Sammanfattning : The p53 tumor suppressor plays an important role in cell fate decisions upon diverse stress conditions. In response to stress, p53 functions as a transcription factor, activating transcription of a variety of its target genes responsible for several cellular responses, most importantly cell cycle arrest and apoptosis. LÄS MER
4. p53 reactivation by the small molecule RITA : molecular mechanisms
Sammanfattning : Inactivation of the tumor suppressor p53 is essential for the development and maintenance of cancer cells. Therefore, reactivation of p53 appears to be a promising strategy for anti-cancer therapy. LÄS MER
5. Molecular mechanisms of growth suppression by pharmacologically activated p53
Sammanfattning : The tumor suppressor p53 is a transcription factor that is crucial for protecting cells from cancer development. The importance of p53 tumor suppression function is highlighted by the fact that the p53 pathway is inactivated in most, if not all cancers. LÄS MER