Sökning: "Mariell Pettersson"

Hittade 1 avhandling innehållade orden Mariell Pettersson.

  1. 1. Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors

    Författare :Mariell Pettersson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interactionProtein-protein interaction; MDM2 p53 interaction; MDM2 inhibitors; α- helix mimetics; β-hairpin; 2; 5-diketopiperazine; spiro-2; 5-diketopiperazine; purine; 8- triazolyl purine; solution conformational analysis; NAMFIS; fluorescence;

    Sammanfattning : Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its involvement in DNA repair, induction of cell cycle arrest and cellular apoptosis. LÄS MER