Sökning: "α- helix mimetics"
Hittade 4 avhandlingar innehållade orden α- helix mimetics.
1. Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors
Sammanfattning : Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its involvement in DNA repair, induction of cell cycle arrest and cellular apoptosis. LÄS MER
2. One key to two doors : Dual targeting peptides and membrane mimetics
Sammanfattning : A targeting peptide at the N-terminus of a precursor protein usually directs the protein synthesized in the cytosol to a specific organelle in the cell. Interestingly, some targeting peptides, so-called dual targeting peptides (dTPs) can target their protein to both mitochondria and chloroplasts. LÄS MER
3. Synthesis of estradiol mimetics and potential anti-Alzheimer’s agents
Sammanfattning : This thesis is composed of two projects, both involving synthesis aimed at drug discovery. The first project covers method development for the synthesis of substances that can be used in estrogen replacement therapy. LÄS MER
4. Purine and Pyrazolopyrimidine Derivatives: Design and Synthesis of Chemical Tools for Biological Applications
Sammanfattning : Purines can be found in a multitude of naturally occurring compounds with a range of functions. This thesis describes the design and synthesis of purines and structurally related pyrazolopyrimidine derivatives intended for biological applications. LÄS MER
