Sökning: "Lena Kjellen"

Visar resultat 11 - 13 av 13 avhandlingar innehållade orden Lena Kjellen.

  1. 11. N-Sulfation and Polymerization in Heparan Sulfate Biosynthesis

    Författare :Jenny Presto; Lena Kjellén; Gunnar Pejler; Anders Malmström; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; Heparan sulfate; N-deacetylase N-sulfotransferase; NDST; EXT1; EXT2; Biosynthesis; Cell- och molekylärbiologi;

    Sammanfattning : Heparan sulfate (HS) is a glycosaminoglycan present in all cell types covalently attached to core proteins forming proteoglycans. HS interacts with different proteins and thereby affects a variety of processes. LÄS MER

  3. 12. Functions of Heparan Sulfate During Mouse Development : Studies of Mice with Genetically Altered Heparan Sulfate Biosynthesis

    Författare :Maria Ringvall; Lena Kjellén; Erik Forsberg; Ulf Lindahl; Erika Gustafsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; embryonic development; gene targeting; lung development; ossification; heparan sulfate; heparin; N-deacetylase N-sulfaotransferase; NDST; proteoglycan; morphogen; biosynthesis; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Heparan sulfate (HS) is a ubiquitous polysaccharide on the cell surface and in the extracellular matrix. HS is an important actor in the regulation of cell signaling, especially in the developing embryo. LÄS MER

  4. 13. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

    Författare :Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

    Sammanfattning : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. LÄS MER