Sökning: "K channels"

Visar resultat 41 - 45 av 147 avhandlingar innehållade orden K channels.

1. 41. Teratogenicity as a consequence of drug-induced embryonic cardiac arrhythmia : Common mechanism for almokalant, sotalol, cisapride, and phenytoin via inhibition of IKr

   Författare :Anna-Carin Sköld; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; IKr; delayed rectifying K channel; embryonic cardiac arrhythmia; teratogenicity; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

   Sammanfattning : During the last years, drugs that prolong the repolarisation phase of the myocardial action potential, due to inhibition of the rapid component of the delayed-rectifying potassium channel (IKr) have been in focus. In addition to arrhythmogenic potential, selective Ikr-blockers have also been shown to be embryotoxic and teratogenic in animal studies. LÄS MER

3. 42. Transducer properties of a mechanoreceptor : an electrophysiological and pharmacological study of the crayfish stretch receptor

   Författare :Jiahui Lin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :stretch receptor; Na channels; K channels; local anesthetics; calmodulin antagonist; patch clamp; voltage clamp;

   Sammanfattning : The abdominal stretch receptor organ of the crayfish, an analog to the human muscle spindle, contains one slowly adapting (SA) and one rapidly adapting (RA) receptor neuron. The general aims of this project were to elucidate, in the SA and RA neurons, the participation of voltagegated Na+ and K+ channels in overall transducer process and adaptation, and to study possible blocking agents specific to mechanosensitive (MS) channels. LÄS MER

4. 43. Regulation of ion transport in the gastrointestinal tract : aspects of early development

   Författare :Lena Grahnquist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Gastrointestinal transport; early development; ontogeny; ion; sodium; potassium; H ; K -ATPase; Na - K - 2Cl- cotransporter; barium-sensitive potassium channels; Na ; K -; ATPase; dopamine; angiotensin II; glucocorticoids; rat; human;

   Sammanfattning : Ion transport in the gastrointestinal tract is vital for cellular homeostasis and to ensure growth during ontogeny. We have therefore investigated the regulation and maturation of sodium, potassium and hydrogen transport in the gastrointestinal tract. Net jejunal sodium absorption is significantly higher in young as compared to adult rats. LÄS MER

5. 44. Mechanisms of adaptation in a mechanoreceptor : a study of mechanical and ionic factors in the crayfish stretch receptors

   Författare :Nuhan Purali; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Crayfish; stretch receptor; adaptation; visco-elastic properties; mechanosensitive channels; potassium channels; sodium channels; gadolinium; tetraethylammonium chloride; 4-amino pyridine; scorpion venom Leiurus quinquestrialus;

   Sammanfattning : The stretch receptor organ of the crayfish, an analog to the human muscle spindle, is a unique preparation for the study of mechanotransduction. The organ consists of a rapidly and a slowly adapting receptor each composed of a receptor muscle fibre into which inserts the dendrites of a multipolar sensory neuron. LÄS MER

7. 45. Patch clamp and calcium studies on human colonic mucosal cells

   Författare :Peter Sand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Human; colon crypt; HT29; K channel; Ca oscillations; volume regulation; patch clamp;

   Sammanfattning : Background: The main function of the large intestine is to fine-tune electrolyte and water balance. This is achieved through the consorted action of ion channels, transporters and pumps. Failures of this system can lead to diarrhoea. LÄS MER