Sökning: "Jeanette Hellgren Kotaleski"

Visar resultat 6 - 10 av 14 avhandlingar innehållade orden Jeanette Hellgren Kotaleski.

  1. 6. A Systems Biological Approach to Parkinson's Disease

    Författare :Katharina F. Heil; Jeanette Hellgren Kotaleski; Olivia Eriksson; J. Douglas Armstrong; Oksana Sorokina; Nigel Williams; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; Neuroscience; Bioinformatics; Network Analysis; Computer Science; Datalogi;

    Sammanfattning : Parkinson’s Disease (PD) is the second most common neurodegenerative disease in the Western world. Itshows a high degree of genetic and phenotypic complexity with many implicated factors, various diseasemanifestations but few clear causal links. Ongoing research has identified a growing number of molecularalterations linked to the disease. LÄS MER

  3. 7. Computer Modelling of Neuronal Interactions in the Striatum

    Författare :Johannes Hjorth; Jeanette Hellgren Kotaleski; Kevin Gurney; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; striatum; fast spiking interneurons; medium spiny projection neurons; gap junctions; interoperability; MUSIC; Computer science; Datavetenskap;

    Sammanfattning : Large parts of the cortex and the thalamus project into the striatum,which serves as the input stage of the basal ganglia. Information isintegrated in the striatal neural network and then passed on, via themedium spiny (MS) projection neurons, to the output stages of thebasal ganglia. LÄS MER

  4. 8. Information processing in the Striatum : a computational study

    Författare :Johannes Hjorth; Jeanette Hellgren Kotaleski; Anders Lansner; Kim Blackwell; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; striatum; fast spiking interneuron; gap junctions; synchronisation; up-state detection; CaMKII; mathematical modelling; Neuroscience; Neurovetenskap;

    Sammanfattning : The basal ganglia form an important structure centrally placed in the brain. They receive input from motor, associative and limbic areas, and produce output mainly to the thalamus and the brain stem. The basal ganglia have been implied in cognitive and motor functions. LÄS MER

  5. 9. Computational modeling of the lamprey CPG : from subcellular to network level

    Författare :Mikael Huss; Jeanette Hellgren Kotaleski; Anders Lansner; Ranu Jung; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Computer science; Datalogi;

    Sammanfattning : Due to the staggering complexity of the nervous system, computer modelling is becoming one of the standard tools in the neuroscientist's toolkit. In this thesis, I use computer models on different levels of abstraction to compare hypotheses and seek un- derstanding about pattern-generating circuits (central pattern generators, or CPGs) in the lamprey spinal cord. LÄS MER

  7. 10. Computational models of lamprey locomotor network neurons

    Författare :Mikael Huss; Jeanette Hellgren Kotaleski; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Datorsystem; Datorsystem; Computer engineering; Datorteknik;

    Sammanfattning : .... LÄS MER