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Visar resultat 16 - 20 av 43 avhandlingar som matchar ovanstående sökkriterier.

1. 16. Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

   Författare :Ida E. Andersson; Jan Kihlberg; Anna Linusson Jonsson; Craig Crews; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; class II MHC; T-cell receptor; rheumatoid arthritis; collagen-induced arthritis; glycopeptide; amide bond isostere; comparative modeling; rational design; molecular docking; molecular dynamics simulation; statistical molecular design; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry; Biorganic Chemistry; bioorganisk kemi; datorlingvistik; computational linguistics;

   Sammanfattning : Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). LÄS MER

3. 17. Redefining the essential molecular aspects that drive interactions between small molecules and G-quadruplex DNA

   Författare :Måns Andréasson; Erik Chorell; Anna Linusson Jonsson; Jan Kihlberg; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G-Quadruplexes; DNA; Oncogenes; G4 ligands; heterocycles; macrocycles; organic synthesis; molecular interactions; rational compound design; medicinal chemistry.; medicinal chemistry; läkemedelskemi; organisk kemi; Organic Chemistry;

   Sammanfattning : G-Quadruplex (G4) structures are secondary nucleic acid structures located in guanine-rich regions of DNA and RNA sequences, involved in gene regulation and cellular maintenance. Efforts to target G4s in a therapeutic setting are scarce, mainly due to vague details about the binding interactions between the ligands and the G4 structure combined with the lack of emphasis on drug-like properties early in the ligand development process. LÄS MER

4. 18. Happy hour? Studies on well-being and time spent on paid and unpaid work

   Författare :Katarina Boye; Jan O. Jonsson; Marie Evertsson; Sonja Drobnič; Stockholms universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Well-being; paid work; housework; gender equality; family policy; parental leave; social comparison; Sweden; Europe; Sociology; Sociologi; Sociology; sociologi;

   Sammanfattning : The present thesis focuses on causes and consequences of paid working hours and housework hours among women and men in Sweden and Europe. It consists of four studies. Study I investigates changes in the division of housework in Swedish couples when they become parents. LÄS MER

5. 19. Children's Living Conditions : Studies on Health, Family and School

   Författare :Sara Brolin Låftman; Jan O. Jonsson; Viveca Östberg; Anne H. Gauthier; Stockholms universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Children; living conditions; well-being; family; health; school; Sweden; Sociology; Sociologi; Sociology; sociologi;

   Sammanfattning : The present dissertation includes four empirical studies, each of which focuses on specific aspects of children’s living conditions. Study I analyses the association between young people’s social relations and health complaints using Swedish nationally representative survey data on 10- to 18-year-olds. LÄS MER

7. 20. Topics in analytic theory of partial differential equations

   Författare :Sergei Chulkov; Jan-Erik Björk; Mattias Jonsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; partial differential equations; Algebra; geometry and mathematical analysis; Algebra; geometri och analys;

   Sammanfattning : The thesis consists of three papers I, II III devoted to some topics in analytic theory of partial differential equations. The main paper is II. In this paper we study a version of the classical problem on the convergence of formal solutions of systems of partial differential equations. LÄS MER