Sökning: "Insulin"

Visar resultat 21 - 25 av 1538 avhandlingar innehållade ordet Insulin.

  1. 21. Interplay between hormones, nutrients and adipose depots in the regulation of insulin sensitivity : an experimental study in rat and human adipocytes

    Författare :Magdalena Lundgren; Jan Eriksson; Jonas Burén; Eva Degerman; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; adipose tissue; cAMP; glucocorticoids; glucose; insulin; insulin resistance; lipolysis; subcutaneous fat; type 2 diabetes; visceral fat; Medicine; Medicin;

    Sammanfattning : Obesity and specifically central obesity is related to insulin resistance, type 2 diabetes and other components of the so-called metabolic syndrome. The aim of this study was to elucidate the interplay between hormones, nutrients and adipose depots in normal and insulin-resistant fat cell metabolism. LÄS MER

  3. 22. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon

    Författare :Linda Ahlkvist; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vagus nerve; GPR119; Insulin resistance; Glucagon; GIP; GLP-1; Insulin;

    Sammanfattning : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. LÄS MER

  4. 23. Mechanisms of insulin exocytosis and release

    Författare :Sebastian Barg; Islet cell physiology; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ClC-3; electrophyiology; confocal microscopy; calcium channel; readily releasable pool; exocytosis; insulin; diabetes; green fluorescent protein; Physiology; Fysiologi;

    Sammanfattning : Endocrine cells as well as neurons release their hormones and transmitters by regulated exocytosis. In the pancreatic B-cell, stimuli like glucose initiate biochemical and electrical processes that culminate in influx of Ca2+, which then triggers exocytosis of insulin-containing granules. LÄS MER

  5. 24. Insulin resistance in skeletal muscle. With special reference to interstitial insulin and glycerol

    Författare :Mikaela Sjöstrand; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin resistance; skeletal muscle; microdialysis; interstitial insulin; interstitial glycerol;

    Sammanfattning : Insulin resistance is a central feature of type 2 diabetes and obesity and is associated with cardiovascular disease. In insulin-resistant muscle, the insulin-mediated glucose uptake is decreased.The delivery of insulin to the interstitial fluid of human skeletal muscle has previously not been investigated. LÄS MER

  7. 25. Regulation of insulin signaling and its developmental and functional roles on peptidergic neurons in the Drosophila central nervous system

    Författare :Jiangnan Luo; Dick Nässel; Susan Broughton; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Insulin; serotonin; octopamine; insulin receptor; Dimm; neuropeptide; funktionell zoomorfologi; Functional Zoomorphology;

    Sammanfattning : In Drosophila, eight insulin-like peptides (DILP1-8) are produced and secreted in different locations. They regulate many aspects of development and physiology, such as organism growth, metabolic homeostasis, reproduction, stress resistance and life span. LÄS MER