Sökning: "Hsf1"
Hittade 3 avhandlingar innehållade ordet Hsf1.
1. Controlling protein homeostasis through regulation of Heat shock factor 1
Sammanfattning : In order to thrive in a changing environment all organisms need to ensure protein homeostasis (proteostasis). Proteostasis is ensured by the proteostasis system that monitors the folding status of the proteome and regulates cell physiology and gene expression to counteract any perturbations. LÄS MER
2. Induction of the heat-shock response by misfolded proteins
Sammanfattning : Cells respond to stress by transcriptional changes intended for stress survival and adaption to further stresses. Heat shock is an intensively studied stress condition that induces in a plethora of physiological changes including increased protein misfolding. LÄS MER
3. The role of T-type calcium channels in human pancreatic β cell maturity
Sammanfattning : This PhD work has optimized a series of in vivo, ex vivo and in vitro approaches to recapitulate, intervene and appraise in vivo maturation of naïve β cells within human induced pluripotent stem cell-derived islets (hiPSC-islets). These approaches have also been applied to characterize hyperglycemia-induced dedifferentiation of mature β cells within native human islets grafted into the anterior chamber of the eye (ACE) of immunodeficient mice. LÄS MER