Sökning: "HIV-I"

Visar resultat 11 - 15 av 18 avhandlingar innehållade ordet HIV-I.

1. 11. Studies on medical and immunological intervention in HIV-1 infection

   Författare :Bo Hejdeman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV; HAART; CD4 ; viral load; treatment interruption; immunotherapy; rgp 160; HIV-1 DNA;

   Sammanfattning : The very first HIV-1 infected patients who received antiretroviral combination therapy (HAART) were severely ill and had very low CD4+ T cell counts. We describe a group of severely ill HIV- I infected patients monitored for the first two years of their HAART. LÄS MER

3. 12. Studies on the efficacy of potent anti-HIV-1 therapy on virological and immunological factors

   Författare :Soo Aleman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The aim of this thesis was to assess to which extent treated human immunodeficiency virus type I (HIV-1) infected patients with a seemingly controlled, defined as undetectable plasma HIV-1 RNA levels (< 50 copies/ml), or low-grade viral replication, exhibited pattems in virological and immunological factors which could suggest a continuation of the disease process. We have therefore analysed the kinetics of HIV-1 DNA levels (Papers I and II), the viral evolution (Paper II), the changes in Beta-chemokine levels (Paper 111) and sCD27 levels (Paper IV), and the appearance of drug resistance associated mutations (Paper V) in such patients. LÄS MER

4. 13. Targeting HIV-1 entry and reverse transcription by vaccination

   Författare :Bartek Zuber; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; DNA vaccination; coreceptor; CCR5; RT; drug resistance; CpG; pseudovirus;

   Sammanfattning : Human immunodeficiency virus type I (HIV-1) is a complex retrovirus, which uses the CD4 receptor and chemokine receptors to infect its target cells. The chemokine receptor CCR5 is essential for primary HIV-1 infection. The hallmark of retroviruses is the enzyme reverse transcriptase (RT), which transcribes the virus genome from RNA to DNA. LÄS MER

5. 14. Molecular dynamics in HIV-1 infection of the brain

   Författare :Mariantonietta Di Stefano; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The focus of the present thesis was to investigate the molecular dynamics in HIV-l infection of the brain. HIV-l infects the brain early during the infection and causes neurological syndromes and neuropathological modifications. LÄS MER

7. 15. The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function

   Författare :Ulrika Mårtensson; Drug Target Discovery; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; HIV SIV; TIG2 chemerin; transcriptional regulation; ligand activation; Co-receptor; GPCR; ChemR23 CMKLR1;

   Sammanfattning : In all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. LÄS MER