Sökning: "GSH"

Visar resultat 21 - 25 av 69 avhandlingar innehållade ordet GSH.

  1. 21. Alpha-class glutathione transferases as steroid isomerases and scaffolds for protein redesign

    Författare :Pär L. Pettersson; Roberta F. Colman; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : The present work focuses on the glutathione transferase (GST) Alpha-class enzymes, their characteristics as steroid isomerases and structural plasticity as malleable scaffolds for protein design. The GSTs are a family of detoxication enzymes that appears to have a wider variety of additional functions. LÄS MER

  3. 22. Drug Delivery to the Brain by Liposomes : Understanding Factors Governing Delivery Outcomes In Vivo

    Författare :Yang Hu; Margareta Hammarlund-Udenaes; Teresa Dalla Costa; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanocarrier; liposome; blood-brain barrier; brain delivery; formulation; methotrexate; diphenhydramine; microdialysis; pharmacokinetics; model-based approach; Farmaceutisk vetenskap; Pharmaceutical Science; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : The blood-brain barrier (BBB) is the primary obstacle for efficient drug delivery to the central nervous system (CNS). One promising strategy to enhance brain delivery is to utilize nanocarriers (NC), e.g., liposomes, encapsulating CNS drugs. LÄS MER

  4. 23. Thioredoxin and glutaredoxin systems under oxidative and nitrosative stress

    Författare :Xiaoyuan Ren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our knowledge about reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been changed from simple damaging molecules to redox signaling mediators. ROS/RNS mediated signaling is mainly based on the reversible post-translational modifications of cysteine which works as a switch for protein functions. LÄS MER

  5. 24. Glutaredoxins : structure, function and mechanism

    Författare :Fredrik Åslund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Thioredoxin (Trx) and glutaredoxin (Grx) are small (9-12 kDa) intracellular disulfide reducing enzymes. They were originally described as hydrogen donors for ribonucleotide reductase (RR), the enzyme that catalyzes the conversion of ribonucleotides to deoxyribonucleotides. LÄS MER

  7. 25. Aspects of cytokinesis with particular emphasis on induction of aneuploidy and determination of the cleavage plane

    Författare :Niklas Schultz; Sluder Greenfiels; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; toxikologisk genetik; Genetic Toxicology;

    Sammanfattning : This thesis focuses primarily on three aspects on cleavage: the relationship between failure of cleavage and aneuploidy; disruption of the cleavage process by hydrophobic chemicals; and the positioning of the spindle and, thus, the cleavage plane. The established Chinese V79 hamster fibroblast cell line was used as the experimental system. LÄS MER