Sökning: "Niklas Schultz"

Hittade 2 avhandlingar innehållade orden Niklas Schultz.

  1. 1. Aspects of cytokinesis with particular emphasis on induction of aneuploidy and determination of the cleavage plane

    Författare :Niklas Schultz; Sluder Greenfiels; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; toxikologisk genetik; Genetic Toxicology;

    Sammanfattning : This thesis focuses primarily on three aspects on cleavage: the relationship between failure of cleavage and aneuploidy; disruption of the cleavage process by hydrophobic chemicals; and the positioning of the spindle and, thus, the cleavage plane. The established Chinese V79 hamster fibroblast cell line was used as the experimental system. LÄS MER

  2. 2. Interplay between Transcription and Homologous Recombination in the Presence of DNA Damage

    Författare :Ivaylo Stoimenov; Thomas Helleday; Niklas Schultz; Natalia Issaeva; Thierry Nouspikel; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; homologous recombination; transcription; DRB; UVC; 6-thioguanine; mammalian cells; BRCA1; BRCA2; PARP inhibitors; XP-V; Molecular biology; Molekylärbiologi; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The biochemical processes of DNA repair, replication and recombination compete for the same substrate, the DNA molecule. This competition is natural, as each process requires the same template. In order to resolve possible conflicts between these processes, when they take place on a particular stretch of DNA, certain crosstalk is expected. LÄS MER