Sökning: "ESPs"

Hittade 5 avhandlingar innehållade ordet ESPs.

  1. 1. Characterization of secreted Giardia intestinalis cysteine proteases

    Författare :Jingyi Liu; Staffan G Svärd; Lars Hellman; Andre Buret; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Giardia intestinalis; ESPs; CPs; apical junction; chemokines; phage display; immunoglobulins; defensins; mucin.; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Giardia intestinalis, the causative agent of the diarrheal disease giardiasis, is a protozoan parasite that colonizes the upper small intestine of mammals, including humans. It can be divided into eight genotypes or assemblages (A through H) and only assemblage A and B are infective to humans. LÄS MER

  3. 2. Genomic and evolutionary exploration of Asgard archaea

    Författare :Eva F. Caceres; Thijs J. G. Ettema; Simonetta Gribaldo; Uppsala universitet; []
    Nyckelord :archaea; Asgard; eukaryogenesis; metagenomics; genome binning; phylogenetics; phylogenomics; comparative genomics; gene tree-species tree reconciliation; ancestral reconstruction; long-read metagenomics;

    Sammanfattning : Current evolutionary theories postulate that eukaryotes emerged from the symbiosis of an archaeal host with, at least, one bacterial symbiont. However, our limited grasp of microbial diversity hampers insights into the features of the prokaryotic ancestors of eukaryotes. LÄS MER

  4. 3. Bifunctional ADAPTs: Opportunity for serological Half-life extension and Targeted therapy

    Författare :Andreas Wisniewski; Sophia Hober; Masood Kamali-Moghaddam; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Autoimmune diseases; Cancer; Half-life extension; HRP; Phage Display; Protein Engineering; Targeted therapy; Biotechnology; Bioteknologi;

    Sammanfattning : Small engineered scaffold proteins (ESPs) gain more and more popularity as biological drugs, due to their specificity and applicability in diagnostics and therapy. Thanks to their high stability, low immunogenicity and low production cost, they present themselves as a promising alternative to the market-leading antibodies. LÄS MER

  5. 4. Studies of Giardia-host interactions: role of cysteine-rich surface proteins

    Författare :Dimitra Peirasmaki; Staffan Svärd; Steven Singer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Giardia; intestinal parasite; parasite infection; host-parasite interaction; virulence factors; HCMPs; cysteine-rich proteins; secretome; proteome;

    Sammanfattning : Giardia intestinalis is a eukaryotic parasite that colonizes the small intestine of humans and animals causing the diarrheal disease known as giardiasis. This parasite is not invasive and does not internalize into host cells but it rather attaches to the brush border surface of the small intestine disrupting the epithelial barrier. LÄS MER

  7. 5. Serglycin-dependent mast cell-specific proteases and their potential interactions with Giardia intestinalis

    Författare :Zhiqiang Li; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Mast cells are located in mucosal and connective tissues throughout the body where they play important roles in immune reactions towards infections. Mast cell deficiency results in failure of clearance of the non-invasive intestinal protozoan parasite Giardia intestinalis in mice, but the mast cell-driven mechanisms remain poorly understood. LÄS MER