Sökning: "Drug delivery system"

Visar resultat 1 - 5 av 112 avhandlingar innehållade orden Drug delivery system.

  1. 1. Nasal Drug Delivery : In Vitro Studies on Factors Influencing Permeability and Implications on Absorption

    Författare :Cecilia Wadell; Frans Merkus; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate implications for drug absorption via the nasal route. LÄS MER

  2. 2. Drug Delivery to the Brain by Liposomes : Understanding Factors Governing Delivery Outcomes In Vivo

    Författare :Yang Hu; Margareta Hammarlund-Udenaes; Teresa Dalla Costa; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanocarrier; liposome; blood-brain barrier; brain delivery; formulation; methotrexate; diphenhydramine; microdialysis; pharmacokinetics; model-based approach; Farmaceutisk vetenskap; Pharmaceutical Science; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : The blood-brain barrier (BBB) is the primary obstacle for efficient drug delivery to the central nervous system (CNS). One promising strategy to enhance brain delivery is to utilize nanocarriers (NC), e.g., liposomes, encapsulating CNS drugs. LÄS MER

  3. 3. A Fully Integrated Microneedle-based Transdermal Drug Delivery System

    Författare :Niclas Roxhed; Göran Stemme; Mark G. Allen; KTH; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microneedle; Transdermal; Intradermal; Drug delivery; DRIE; MEMS; Microsystem; Medical technology; Medicinsk teknik;

    Sammanfattning : Patch-based transdermal drug delivery offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections relating to issues such as patient acceptability and injection safety. However, conventional transdermal drug delivery is limited to therapeutics where the drug can diffuse across the skin barrier. LÄS MER

  4. 4. Biopharmaceutical Evaluation of Intra-arterial Drug-Delivery Systems for Liver Cancer : Investigations in healthy pigs and liver cancer patients

    Författare :Elsa Lilienberg; Hans Lennernäs; Erik Sjögren; Niklas Axén; Helen M. Burt; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vivo release; drug delivery systems; local delivery; drug disposition; doxorubicin; hepatocellular carcinoma; transarterial chemoembolization; transarterial chemotherapy infusion; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : There are currently two types of intra-arterial drug-delivery system (DDS) in clinical use in the palliative treatment of primary liver cancer. The chemotherapeutic drug doxorubicin (DOX) can be formulated into a drug-in-lipiodol emulsion (LIPDOX) or a microparticulate drug-eluting bead system (DEBDOX). LÄS MER

  5. 5. Nonlinear Modeling and Feedback Control of Drug Delivery in Anesthesia

    Författare :Margarida M. Silva; Alexander Medvedev; Teresa Mendonça; Torbjörn Wigren; Robain De Keyser; Uppsala universitet; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; anesthesia; drug delivery; feedback control; nonlinear modeling; pharmacokinetics pharmacodynamics; PID control; system identification; Wiener model; Elektroteknik med inriktning mot reglerteknik; Electrical Engineering with specialization in Automatic Control;

    Sammanfattning : General anesthesia is a drug-induced reversible state where neuromuscular blockade (NMB), hypnosis, and analgesia (jointly denoted by depth of anesthesia - DoA) are guaranteed. This thesis concerns mathematical modeling and feedback control of the effect of the muscle relaxants atracurium and rocuronium, the hypnotic propofol, and the analgesic remifentanil. LÄS MER