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Visar resultat 1 - 5 av 11 avhandlingar som matchar ovanstående sökkriterier.
1. In search of a biosensor for DNT detection : Studies of inducer response and specificity of DntR
Sammanfattning : The primary aim of the work presented in this thesis was to change the inducer specificity of the DntR protein in order to improve the response to DNT. The long-term goal is to use this protein in a biosensor for DNT, a signature compound for detection of the explosive TNT. LÄS MER
2. Novel Endpoints To Unravel Developmental Neurotoxicity : From DNA methylation responses to methylmercury to the in vitro identification of endocrine disruptors
Sammanfattning : The developing brain is especially sensitive to environmental stressors due to its dependence on the precise spatiotemporal regulation of multiple signals, and the long time period required for its formation. Some chemicals can interfere with molecular and cellular processes driving brain development, including epigenetic processes such as DNA methylation. LÄS MER
3. Data-Centric Network of Things : A Method for Exploiting the Massive Amount of Heterogeneous Data of Internet of Things in Support of Services
Sammanfattning : Internet of things (IoT) generates massive amount of heterogeneous data, which should be efficiently utilized to support services in different domains. Specifically, data need to be supplied to services by understanding the needs of services and by understanding the environment changes, so that necessary data can be provided efficiently but without overfeeding. LÄS MER
4. Developmental Neurotoxicity Testing Using In vitro Approaches
Sammanfattning : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. LÄS MER
5. Neurodevelopmental Consequences of Exposure to Paracetamol (Acetaminophen) and Related Drugs : Experimental studies in mice
Sammanfattning : Paracetamol (acetaminophen) is the analgesic pharmaceutical most commonly used during pregnancy and early life. While therapeutic doses of paracetamol are considered harmless during these periods, recent findings in both humans and rodents suggest a link between developmental exposure to paracetamol and behavioral consequences later in life. LÄS MER