Sökning: "DNA methylation test"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden DNA methylation test.

  1. 1. SOX11 as a Cancer Biomarker - Expression and Regulatory Studies in B-cell Lymphomas and Ovarian Cancer

    Författare :Elin Gustavsson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SOX11; B-cell lymphomas; DNA methylation; cancer biomarkers; ovarian cancer;

    Sammanfattning : It is estimated that one third of all people in Sweden will be diagnosed with cancer during their lifetime. The outcome for a specific patient is related to early and correct diagnosis, and prediction of effective treatment regimens. Biomarkers are molecules that can aid the clinician in such decisions regarding diagnosis, prognosis and therapy. LÄS MER

  3. 2. Pituitary Tumor Surgery - factors influencing outcome

    Författare :Tobias Hallén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endoscopic transsphenoidal surgery; biomarkers; glial fibrillary acidic protein; neurofilaments; tau protein; pituitary tumors; sinonasal health; tumor progression; predictive markers; MCM7; methylation patterns; NFPA;

    Sammanfattning : Background: Pituitary tumors represent 15–20% of intracranial tumors. The majority are benign adenomas, of which 30 % are hormonally inactive, the non-functioning pituitary adenomas (NFPAs). LÄS MER

  4. 3. Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'

    Författare :Ying Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Elimination test; common eliminated region 1 CER1 ; 3p21.3; microcell hybrids; tumor suppressor gene; LF lactoferrin ; LIMD1 LIM-domain containing gene 1 ; sequencing; MMCT microcell mediated chromosome transfer ; real time PM methylation;

    Sammanfattning : The aim of elimination test (Et) is to identify tumor antagonizing genes from chromosome regions that are regularly deleted in microcell hybrid (MCH) derived tumors through serial SCID mice passages. Et so far was focused on the short arm of human chromosome 3 (chr 3) due to its frequent deletions in 21 tumor types including renal cell carcinoma (RCC), small cell lung carcinoma (SCLC) and breast cancer (BRC). LÄS MER

  5. 4. Prader-Willi syndrome : diagnosis and effects of growth hormone treatment

    Författare :Ann Christin Lindgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA methylation test; genomic imprinting; glucose intolerance; growth hormone; Prader Willi syndrome; respiratory function;

    Sammanfattning : Prader-Willi syndrome (PWS) is a rare neurogenetic disorder characterised by hypotonia (especially pronounced in the perinatal period) with "failure to thrive", hypogonadism, hypoventilation, dysmorphic features, final short stature and mental retardation. From the age of 2 years hyperphagia develops leading to obesity if the caloric intake is not limited. LÄS MER

  7. 5. Early oncogenic events and defective apoptosis in prostate cancer

    Författare :Xiaolei Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Prostate cancer; HGPIN; ezrin; pim-1; XAF1; apoptosis; DNA methylation; immunohistochemistry; FISH;

    Sammanfattning : Prostate cancer is one of the most common malignancies in males in the Western world. Although the mechanisms are unclear, it is generally believed that the accumulation of genetic alterations leads to the tumor formation. LÄS MER