Sökning: "SOX11"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet SOX11.

  1. 1. SOX11 in Mantle Cell Lymphoma - Novel Tools for Diagnostic, Prognostic and Functional Investigations

    Författare :Lena Nordström; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibodies; DNA methylation; Epigenetics; SOX11; Lymphoma;

    Sammanfattning : The goal of biomarker discovery is to identify disease defining molecules, which could be used to improve early detection and/or to predict survival and response to treatment. This thesis is about the transcription factor SOX11, a protein discovered in the context of mantle cell lymphoma in 2008, which shows great potential to be used as a clinical relevant biomarker. LÄS MER

  3. 2. SOX11 as a Cancer Biomarker - Expression and Regulatory Studies in B-cell Lymphomas and Ovarian Cancer

    Författare :Elin Gustavsson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SOX11; B-cell lymphomas; DNA methylation; cancer biomarkers; ovarian cancer;

    Sammanfattning : It is estimated that one third of all people in Sweden will be diagnosed with cancer during their lifetime. The outcome for a specific patient is related to early and correct diagnosis, and prediction of effective treatment regimens. Biomarkers are molecules that can aid the clinician in such decisions regarding diagnosis, prognosis and therapy. LÄS MER

  4. 3. A Molecular Dissection of Mantle Cell Lymphoma - From gene expression analysis to functional evaluation of selected targets

    Författare :Venera Kuci; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; side population; deoxycytidine kinase; resistance; SOX11; mantle cell lymphoma;

    Sammanfattning : Mantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. LÄS MER

  5. 4. Burkitt lymphoma and diffuse large B-cell lymphoma – therapeutic strategies and pathogenetic mechanisms

    Författare :Tove Wästerlid; Tumörmikromiljö; []
    Nyckelord :Burkitt Lymphoma; Chemotherapy; SOX11; Diffuse large B-cell lymphoma; Prognostic factors; Rituximab;

    Sammanfattning : Burkitt lymphoma (BL) is a rare, aggressive disorder constituting 1% of all non-Hodgkin lymphoma. Diffuse large B-cell lymphoma (DLBCL) is more common, accounting for 30% of malignant lymphoma. Standard treatment for adult BL and for certain subgroups of patients with DLBCL remains to be defined due to paucity of randomised trials performed. LÄS MER

  7. 5. New molecular markers in mantle cell lymphoma : studies of cannabinoid receptors, 5-lipoxygenase and SOX11

    Författare :Xiao Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that accounts for 5-10% of all lymphomas and tends to occur in older adults with a higher incidence in males. The genetic hallmark of this neoplasm is the t(11;14) translocation which results in overexpression of nuclear cyclin D1. LÄS MER