Sökning: "pim-1"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet pim-1.

  1. 1. Molecular Studies of Diamond-Blackfan Anemia and Congenital Nail Dysplasia

    Författare :Anne-Sophie Fröjmark; Niklas Dahl; Catharina Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diamond-Blackfan Anemia; RPS19; RPS24; PIM-1; Erythropoiesis; Cell cycle; Apoptosis; Nail dysplasia; FZD6; WNT signaling; Clinical genetics; Klinisk genetik;

    Sammanfattning : The aim of this thesis is to investigate the effect of genetic mutations on the pathophysiology of two human disorders: Diamond-Blackfan Anemia (DBA) and isolated congenital nail dysplasia. The first part of this thesis (Paper I-III) investigates the mechanism associated with DBA. LÄS MER

  3. 2. Nanoplasmonic Sensing of Materials for Energy Applications

    Författare :Ferry Nugroho; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; localized surface plasmon resonance; sensors; palladium; PIM-1; microporous polymers; nanofabrication; film thickness dependence; indirect nanoplasmonic sensing; glass transition temperature; carbon capture and storage; adsorption; polymer:fullerene blends; organic photovoltaics; alloy nanoparticles; hydrogen sensors; plasmonic sensors;

    Sammanfattning : Sensors are omnipresent in our daily life. They are used in many applications ranging from the touch screen in our smartphones to more critical contexts such as pollution monitoring. LÄS MER

  4. 3. Early oncogenic events and defective apoptosis in prostate cancer

    Författare :Xiaolei Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Prostate cancer; HGPIN; ezrin; pim-1; XAF1; apoptosis; DNA methylation; immunohistochemistry; FISH;

    Sammanfattning : Prostate cancer is one of the most common malignancies in males in the Western world. Although the mechanisms are unclear, it is generally believed that the accumulation of genetic alterations leads to the tumor formation. LÄS MER

  5. 4. Ribosomal Proteins in Diamond-Blackfan Anemia : Insights into Failure of Ribosome Function

    Författare :Jitendra Badhai; Niklas Dahl; Anthony Wright; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diamond-Blackfan anemia; RPS19; Ribosomal proteins; Haploinsufficiency; cell cycle; Apoptosis; Erythropoiesis; Medical genetics; Medicinsk genetik; Clinical Genetics; klinisk genetik;

    Sammanfattning : Diamond-Blackfan anemia (DBA) is a severe congenital anemia characterized by a defect in red blood cell production. The disease is associated with growth retardation, malformations, a predisposition for malignant disease and heterozygous mutations in either of the ribosomal protein (RP) genes RPS7, RPS17, RPS19, RPS24, RPL5, RPL11 and RPL35a. LÄS MER

  7. 5. A study of the transition from premalignancy to clinical prostate cancer

    Författare :Alexander Valdman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Prostate cancer; immunohistochemistry; prostatic intraepithelial neoplasia; aspiration cytology;

    Sammanfattning : Prostate cancer remains the most commonly diagnosed life-threatening malignancy and the second leading cause of death from cancer in men. However, little is known about molecular mechanisms that underline its initiation and progression. LÄS MER