Sökning: "genomic imprinting"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden genomic imprinting.

1. 1. Epigenetic Control of Mammalian Development : Studies on an imprinting control region

   Författare :Liang Liu; Pärt Peterson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Epigenetic; Genomic imprinting; DNA methylation; Igf2; H19; Insulator; CTCF; Imprinting control region; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; zoologisk utvecklingsbiologi; Animal Development;

   Sammanfattning : A subset of autosomal genes is preferentially or exclusively expressed from one of the parental alleles. This phenomenon, termed genomic imprinting, is highlighted by the neighboring Igf2 and H19 genes, which are monoallelically expressed on opposite parental chromosomes. These features are governed by a 2. LÄS MER

3. 2. Epigenetic Regulation of Genomic Imprinting and Higher Order Chromatin Conformation

   Författare :Gholamreza Tavoosidana; Rolf Ohlsson; Job Dekker; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Epigenetic; Imprinting; Chromatin; CTCF; H19 ICR; 4C; Utvecklingsbiologi; Biology; Biologi;

   Sammanfattning : The genetic information encoded by the DNA sequence, can be expressed in different ways. Genomic imprinting is an epigenetic phenomenon that results in monoallelic expression of imprinted genes in a parent of origin-dependent manner. Imprinted genes are frequently found in clusters and can share common regulatory elements. LÄS MER

4. 3. Long-range Control of Gene Expression by Imprinting Control Regions During Development and Neoplasia

   Författare :Noopur Thakur; Chandrasekhar Kanduri; Thomas Ekstrom; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Genomic imprinting; Imprinting control region; Antisense RNA; de novo methylation; Molekylärbiologi; Molecular biology; Molekylärbiologi;

   Sammanfattning : Genomic imprinting is an epigenetic phenomenon by which a subset of genes is expressed in a parent of origin specific manner. Most of the imprinted genes are located in clusters. Genetic evidences suggest that genes in imprinted clusters are regulated by Imprinting Control Regions (ICRs). LÄS MER

5. 4. Genomic Imprinting in Development and Evolution

   Författare :Joanne Whitehead; Rolf Ohlsson; Andras Paldi; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

   Sammanfattning : Genetic information is encoded by the linear sequence of the DNA double helix, while epigenetic information is overlayed as the packaging of DNA and associated proteins into the chromatin structure. Variations in chromatin structure play a vital role in establishing and maintaining patterns of gene expression during differentiation and development of higher eukaryotes, and disruption of this epigenetic gene regulation can lead to cancer. LÄS MER

7. 5. Long Noncoding RNA Mediated Regulation of Imprinted Genes

   Författare :Faizaan Mohammad; Chandrasekhar Kanduri; Kristian Helin; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genomic imprinting; noncoding RNA; epigenetics; chromatin; DNA methylation; Developmental biology; Utvecklingsbiologi; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : Genomic imprinting is an epigenetic phenomenon that causes a subset of mammalian genes to be expressed from only one allele in a parent-of-origin manner. The defects in the imprinting regulation result in disorders that affect development, growth and metabolism. LÄS MER