Sökning: "Congenic"

Visar resultat 6 - 10 av 72 avhandlingar innehållade ordet Congenic.

  1. 6. Functional and genetic analyses of the MHC and its impact on autoimmunity in the rat

    Författare :Jonatan Tuncel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The major histocompatibility complex (MHC) is an allele-rich and exceptionally gene dense region on human chromosome 6. Over 40% of the genes in this region have immune-related functions, including genes encoding MHCI and MHCII molecules. These molecules, which are found in nearly all vertebrates, present antigenic peptides to CD4 and CD8 T cells. LÄS MER

  3. 7. Islet insulin secretory patterns in diabetes and the role of UCP2

    Författare :Jian-Man Lin; Valdemar Grill; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; type 1 diabetes; type 2 diabetes; NOD; GK; congenes; KKAy; human; islet; glucose; insulin release; oscillation; frequency; amplitude; oxidation; respiration; UCP2; western blot; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : During development of type 1 and type 2 diabetes plasma insulin patterns are altered. Since the islet insulin release pattern has been implicated in this development, insulin secretion from single islets was studied and linked to the islet protein levels of uncoupling protein-2 (UCP2). LÄS MER

  4. 8. A sub-phenotype approach to dissect the genetic control of murine type 1 diabetes

    Författare :Marie-Louise Bergman; Leif Andersson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes (T1D). The disease in the NOD mouse is polygenic and multifactorial and so far at least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified. However, no etiological mutations have been definitely ascribed to the Idd loci. LÄS MER

  5. 9. From disease to genes in animal models of rheumatoid arthritis and multiple sclerosis

    Författare :Therese Lindvall; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mice; animal models; autoimmunity; CIA; EAE; RA; MS;

    Sammanfattning : Rheumatoid arthritis (RA) and multiple sclerosis (MS) are complex inflammatory autoimmune diseases. The aetiology is largely unknown but the risk of developing disease is dependent on both genetic and environmental factors. LÄS MER

  7. 10. Genetic regulation of autoimmune neuroinflammation

    Författare :Kristina Becanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MS; EAE; QTL; gene regulation; linkage analysis;

    Sammanfattning : Multiple sclerosis (MS) is a complex disease characterized by inflammation and demyelination in the central nervous system (CNS), causing neurological deficits. Although there is an increased familial aggregation rate and evidence for a genetic influence on disease susceptibility, environmental factors are also of importance. LÄS MER