Sökning: "UCP2"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet UCP2.

  1. 1. Islet insulin secretory patterns in diabetes and the role of UCP2

    Författare :Jian-Man Lin; Valdemar Grill; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; type 1 diabetes; type 2 diabetes; NOD; GK; congenes; KKAy; human; islet; glucose; insulin release; oscillation; frequency; amplitude; oxidation; respiration; UCP2; western blot; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : During development of type 1 and type 2 diabetes plasma insulin patterns are altered. Since the islet insulin release pattern has been implicated in this development, insulin secretion from single islets was studied and linked to the islet protein levels of uncoupling protein-2 (UCP2). LÄS MER

  3. 2. Genetics of type 2 diabetes and the metabolic syndrome

    Författare :Mia Klannemark; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; PDE3B; PPARG; LPL; metabolic syndrome; diabetes; genetic; HSL; UCP2; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Type 2 diabetes and the metabolic syndrome are highly prevalent disorders with severe complications such as cardiovascular disease. The aetiology of type 2 diabetes and the metabolic syndrome is not known, but the interaction between genetic factors and environmental triggers is important. LÄS MER

  4. 3. Molecular mechanisms of weight regulation in obesity and chronic renal failure with special reference to leptin and uncoupling protein 2

    Författare :Louise Nordfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adipose tissue; BMI; chronic renal failure CRF ; gene expression; in situ hybridization; leptin; obesity; peritoneal dialysis PD ; single nucleotide polymorphism SNP ; UCP2; UCP2-polymorphism;

    Sammanfattning : Obesity, which increases the risk of developing serious medical disorders, such as cardiovascular disease and diabetes, is threatening to become a global epidemic, meaning escalating healthcare costs for society and reduced quality of life for the individual. Thus, there is a large unmet need for improved preventive strategies and effective treatments. LÄS MER

  5. 4. On obesity in acute pancreatitis

    Författare :Ralf Segersvärd; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute pancreatitis; animal; cytokines; dietary fats; fatty liver; endotoxin; hypertriglyceridemia; interleukines; lipopolysaccharides; liver diseases; mice; mortality; obesity; oxidative stress; pancreas; survival; tumor necrosis factor; rats; UCP2; uncoupling proteins.;

    Sammanfattning : Over-nutrition is one of today s most visible public health problems. Currently over 40% of the Swedish population is either overweight or obese. Acute pancreatitis (AP) is an acute inflammatory process of the pancreas with variable involvement of regional tissues and/or remote organ systems. LÄS MER

  7. 5. Molecular mechanisms of aging in MTDNA mutator mice

    Författare :Daniel Henry Sven Edgar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mitochondria are intensely studied in the field of aging. mtDNA mutator mice have a proofreading deficiency in the mitochondrial DNA polymerase POLG, which causes a large amount of point mutations to be accumulated in mitochondrial DNA. These mice have mitochondrial dysfunction and experience a range of premature aging phenotypes. LÄS MER