Sökning: "Cbl"

Visar resultat 6 - 10 av 23 avhandlingar innehållade ordet Cbl.

  1. 6. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy

    Författare :Haisha Ma; Johan Lennartsson; Håkan Axelson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; Ras; macropinocytosis; Fer; STAT3; HD-PTP; Cbl; ubiquitination; pericyte; vasculature; tumor; ASKA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. LÄS MER

  3. 7. Mechanisms of modulation of PDGFRβ signaling

    Författare :Niki Sarri; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signalling; phosphatase; MKP2; DUSP4; deubiquitinase; USP4; USP17; E3 ligase; Cbl; TRIM21; endoribonuclease; G3BP1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Platelet-derived growth factors (PDGF) constitute a family of five functional dimers that bind to two structurally related tyrosine kinase receptors i.e. PDGF receptor α and β (PDGFRα and PDGFRβ, respectively), controlling cell growth, proliferation, and migration in cells of mesenchymal origin. LÄS MER

  4. 8. ß2 integrin-induced signal transduction events in human neutrophils

    Författare :Fredrik Melander; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; integrins; signal transduction; Rho GTPases; kinases; c-Cbl; General pathology; patologisk anatomi; pathological anatomy; Patologi allmän ; neutrophils;

    Sammanfattning : Inflammation is a localized protective response in vascularized tissues and can be induced by microbial infection or cell and tissue injury. Polymorphonuclear neutrophils (PMN) are the most common white blood cells and are recognized as major cellular mediators of acute inflammation. LÄS MER

  5. 9. Spacing Law and Politics : The constitution and representation of judicial places and juridical spaces in law, literature and political philosophy in works from Greek antiquity to the present

    Författare :Leif Dahlberg; Carol Jacobs; Haun Saussy; Yale University (USA); []
    Nyckelord :HUMANIORA; HUMANITIES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES;

    Sammanfattning : The dissertation studies judicial places and juridical spaces, constituted and represented in a variety of media as well as material objects and physical buildings, exploring the inherent spatiality of law, both theoretically and as social practice. The judicial places and juridical spaces analysed in the dissertation have diverse forms and functions and are analysed from different perspectives, allowing for a historical and genealogical understanding of the spacing of law and politics. LÄS MER

  7. 10. TRIBOCHEMICAL INTERACTIONS OF A PTFE/ALPHA ALUMINA COMPOSITE AT THE SLIDING INTERFACE: A MECHANISM FOR ULTRA LOW WEAR

    Författare :Kathryn L Harris; USA University of Florida; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : The wear and friction behavior of ultralow wear polytetrafluoroethylene (PTFE)/αalumina composites first described by Burris and Sawyer in 2006 has been studied intensively in the years hence. The mechanisms responsible for the remarkable improvement in wear over unfilled PTFE are not yet fully understood. LÄS MER