Sökning: "E3 ligase"

Visar resultat 1 - 5 av 78 avhandlingar innehållade orden E3 ligase.

  1. 1. A study on the E3 ligase TRIM21/Ro52

    Författare :Alexander Espinosa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti-TRIM21/Ro52 autoantibodies is used as a diagnostic tool, the biological function of TRIM21/Ro52 is still unknown. LÄS MER

  3. 2. Mechanisms of modulation of PDGFRβ signaling

    Författare :Niki Sarri; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signalling; phosphatase; MKP2; DUSP4; deubiquitinase; USP4; USP17; E3 ligase; Cbl; TRIM21; endoribonuclease; G3BP1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Platelet-derived growth factors (PDGF) constitute a family of five functional dimers that bind to two structurally related tyrosine kinase receptors i.e. PDGF receptor α and β (PDGFRα and PDGFRβ, respectively), controlling cell growth, proliferation, and migration in cells of mesenchymal origin. LÄS MER

  4. 3. The TRIM21/Ro52 E3 ligase and its antibodies in autoimmune disease

    Författare :Aurélie Ambrosi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Patients with the systemic autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) often have autoantibodies against Ro/SSA (composed of the TRIM21/Ro52 and Ro60 antigens) and La/SSB. The biological function of the TRIM21/Ro52 protein itself has remained unknown until its recent description as a tripartite-motif (TRIM) family member and an E3 ligase involved in ubiquitination. LÄS MER

  5. 4. Functional Characterization of the Yeast Tumour Suppressor Homologue Sro7p

    Författare :Annabelle Forsmark; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yeast; protein sorting; protein secretion; L 2 GL; tumour suppressor; SRO7; SRO77; ENA1; exocytosis; post-Golgi vesicles; ART5; E3 adaptor; ubiquitylation; ATLGL1; ATLGL2;

    Sammanfattning : Correct targeting of newly synthesized proteins to appropriate domains of the cell membrane is crucial to cellular architecture, polarity and function, making it no surprise that many proteins of the secretory machinery are conserved throughout evolution. This work presents a functional characterisation of the Saccharomyces cerevisiae cell polarity protein and tumour suppressor homologue, Sro7p. LÄS MER

  7. 5. Interplay between the Myc oncoprotein, cyclin-dependent kinases and E3 ubiquitin ligases

    Författare :Hamid Reza Sharifi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mammalian cells grow, divide, and die in a precise and orderly fashion. For cells to grow and maintain their integrity they need to communicate at both intracellular and extracellular level. LÄS MER